Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1930980..1931482 | Replicon | chromosome |
| Accession | NZ_CP055199 | ||
| Organism | Shigella flexneri strain STEFF_3 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | HUZ39_RS09280 | Protein ID | WP_072663248.1 |
| Coordinates | 1931228..1931482 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUZ39_RS09275 | Protein ID | WP_001259255.1 |
| Coordinates | 1930980..1931231 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ39_RS09250 (1926159) | 1926159..1927226 | - | 1068 | WP_000080102.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| HUZ39_RS09255 (1927226) | 1927226..1928296 | - | 1071 | WP_061353533.1 | histidinol-phosphate transaminase | - |
| HUZ39_RS09260 (1928293) | 1928293..1929597 | - | 1305 | WP_061353534.1 | histidinol dehydrogenase | - |
| HUZ39_RS09265 (1929603) | 1929603..1930502 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HUZ39_RS09270 (1930647) | 1930647..1930697 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUZ39_RS09275 (1930980) | 1930980..1931231 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUZ39_RS09280 (1931228) | 1931228..1931482 | + | 255 | WP_072663248.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUZ39_RS09285 (1931565) | 1931565..1932389 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| HUZ39_RS09290 (1932435) | 1932435..1933364 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| HUZ39_RS09295 (1933579) | 1933579..1933641 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUZ39_RS09300 (1933631) | 1933631..1934989 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUZ39_RS09305 (1935168) | 1935168..1936226 | + | 1059 | WP_000492305.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUZ39_RS09310 (1936240) | 1936240..1936467 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10231.67 Da Isoelectric Point: 8.8202
>T161901 WP_072663248.1 NZ_CP055199:1931228-1931482 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKYTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKYTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T161901 NZ_CP071395:144117-144401 [Klebsiella michiganensis]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGTTAGGTCATACACTACAGGTGCAGTTCAA
AAAGAAGCTCAAAGAGCGTCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGATCAATATAAAATTA
AGCTTCTTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAAGACGACATTGTCACAGTCACTGTTATCGGCGTAGGTAAA
CGCGAAAACGACGACATTTATAATGCAACCCTGAATCGCAATTGA
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGTTAGGTCATACACTACAGGTGCAGTTCAA
AAAGAAGCTCAAAGAGCGTCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGATCAATATAAAATTA
AGCTTCTTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAAGACGACATTGTCACAGTCACTGTTATCGGCGTAGGTAAA
CGCGAAAACGACGACATTTATAATGCAACCCTGAATCGCAATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT161901 WP_001259255.1 NZ_CP055199:1930980-1931231 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT161901 NZ_CP071395:143879-144127 [Klebsiella michiganensis]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCCAGCATTACTGAGCTTAAACGTGACCCTATGGGTACTTTCCACGCTGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTATTGCGTGCCACCGGCACTATACGCCCAGTTGA
TGGAACTACTGGAAGACGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGGGAAAGGGTTATCGAGGTCAATATCGAT
GACCTATAA
ATGGCATTTCAGGTTCTGACCACTACAGCAGCCAGCATTACTGAGCTTAAACGTGACCCTATGGGTACTTTCCACGCTGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTATTGCGTGCCACCGGCACTATACGCCCAGTTGA
TGGAACTACTGGAAGACGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGGGAAAGGGTTATCGAGGTCAATATCGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|