Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 52469..52733 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP055196 | ||
| Organism | Shigella flexneri strain STEFF_10 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | HUZ40_RS24560 | Protein ID | WP_001331364.1 |
| Coordinates | 52581..52733 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 52469..52526 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ40_RS24545 (47708) | 47708..49999 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| HUZ40_RS24550 (49992) | 49992..51062 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| HUZ40_RS24555 (51081) | 51081..52289 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (52469) | 52469..52526 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (52469) | 52469..52526 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (52469) | 52469..52526 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (52469) | 52469..52526 | - | 58 | NuclAT_0 | - | Antitoxin |
| HUZ40_RS24560 (52581) | 52581..52733 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| HUZ40_RS24565 (52805) | 52805..53056 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| HUZ40_RS25360 (53555) | 53555..53650 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| HUZ40_RS24575 (53715) | 53715..53891 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| HUZ40_RS24580 (54283) | 54283..54492 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| HUZ40_RS24585 (54564) | 54564..55214 | - | 651 | WP_001178506.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| HUZ40_RS24590 (55288) | 55288..57456 | - | 2169 | WP_021265679.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 | - | 1..99313 | 99313 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T161888 WP_001331364.1 NZ_CP055196:52581-52733 [Shigella flexneri]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T161888 NZ_CP071393:661218-661592 [Klebsiella michiganensis]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTGGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTGGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA
Antitoxin
Download Length: 58 bp
>AT161888 NZ_CP055196:c52526-52469 [Shigella flexneri]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
