Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 100361..100787 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055195 | ||
| Organism | Shigella flexneri strain STEFF_10 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ40_RS24095 | Protein ID | WP_001372321.1 |
| Coordinates | 100361..100486 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 100563..100787 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ40_RS24055 (95735) | 95735..96424 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ40_RS24060 (96611) | 96611..96994 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ40_RS24065 (97315) | 97315..97917 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ40_RS24070 (98214) | 98214..99035 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ40_RS24075 (99153) | 99153..99440 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ40_RS24080 (99465) | 99465..99671 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ40_RS24085 (99741) | 99741..99913 | + | 173 | Protein_113 | hypothetical protein | - |
| HUZ40_RS24090 (99911) | 99911..100141 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ40_RS24095 (100361) | 100361..100486 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ40_RS24100 (100428) | 100428..100577 | - | 150 | Protein_116 | plasmid maintenance protein Mok | - |
| - (100563) | 100563..100787 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (100563) | 100563..100787 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (100563) | 100563..100787 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (100563) | 100563..100787 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ40_RS24105 (100599) | 100599..100787 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ40_RS24110 (100756) | 100756..101518 | - | 763 | Protein_118 | plasmid SOS inhibition protein A | - |
| HUZ40_RS24115 (101515) | 101515..101949 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ40_RS24120 (102004) | 102004..102201 | - | 198 | Protein_120 | hypothetical protein | - |
| HUZ40_RS24125 (102229) | 102229..102462 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ40_RS24130 (102530) | 102530..103069 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ40_RS24135 (103095) | 103095..103301 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ40_RS24140 (103371) | 103371..103451 | + | 81 | Protein_124 | hypothetical protein | - |
| HUZ40_RS24145 (103634) | 103634..103803 | - | 170 | Protein_125 | hypothetical protein | - |
| HUZ40_RS24150 (104397) | 104397..105368 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / catA2 / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..125749 | 125749 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161884 WP_001372321.1 NZ_CP055195:c100486-100361 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161884 NZ_CP071386:29672-30142 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 225 bp
>AT161884 NZ_CP055195:c100787-100563 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
