Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 596878..597677 Replicon chromosome
Accession NZ_CP055194
Organism Shigella flexneri strain STEFF_10

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6H2GMC5
Locus tag HUZ40_RS02915 Protein ID WP_000347279.1
Coordinates 596878..597342 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HUZ40_RS02920 Protein ID WP_001307405.1
Coordinates 597342..597677 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ40_RS02885 (591879) 591879..592313 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
HUZ40_RS02890 (592331) 592331..593209 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
HUZ40_RS02895 (593199) 593199..593978 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
HUZ40_RS02900 (593989) 593989..594462 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUZ40_RS02905 (594485) 594485..595765 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUZ40_RS02910 (596014) 596014..596823 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUZ40_RS02915 (596878) 596878..597342 - 465 WP_000347279.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUZ40_RS02920 (597342) 597342..597677 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUZ40_RS02925 (597826) 597826..599397 - 1572 WP_001273741.1 galactarate dehydratase -
HUZ40_RS02930 (599772) 599772..601106 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HUZ40_RS02935 (601122) 601122..601892 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17869.24 Da        Isoelectric Point: 9.4947

>T161855 WP_000347279.1 NZ_CP055194:c597342-596878 [Shigella flexneri]
MDFPQRVNGWVLYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESFTQETEENH

Download         Length: 465 bp

>T161855 NZ_CP071382:206093-206389 [Geobacter sp. Jerry-YX]
ATGGCCAAGACTGCTACCAGTCGTTATGATGTCGCGGAACATCTCCGTACTCCGGAAGAAATGGCGGCCTATCTTGAAGC
ATCGCTCGAAGAGGCTAATGGTGATGCAGCTTTCATTGCCAAAGCCCTCGGCGACATAGCCCGAGCCAAAGGGATGTCTC
AAGTGGCGCGCGATGCCGGTCTTTCTCGTGAAAGTCTTTACAAGGCACTTTCAGGTGAGCGGGTGCCTGGTTTTGATACT
ATTTTAAAAGTCGTTTCAGCACTGGGACTCAAACTTCATGCAGAGGCCGCTCACTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT161855 WP_001307405.1 NZ_CP055194:c597677-597342 [Shigella flexneri]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT161855 NZ_CP071382:205793-206083 [Geobacter sp. Jerry-YX]
ATGGTTGAAATCCGCAAAACCGAGCATTTTGCCAACTGGCTCGACAACTTACGTGATATCCAGGCGAAGGCTCGTGTCCT
TGTAAGGATTGAGCGTCTTGCTTCTGGAAACGCAGGTGACGTCAAGCCTGTGGGTGAAGGTGTCTCGGAAATGCGGATCA
ACTACGGTCCCGGTTATCGAGTTTATTTTATTCAACGCGGCAGCGAATTGATCATCCTGTTGGCCGGTGGCGACAAGAGC
AGCCAGTCTCGGGATATCAAGGCAGCTGTCCGGCTTGCTCAGAACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GMC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References