Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3641505..3642199 | Replicon | chromosome |
| Accession | NZ_CP055181 | ||
| Organism | Shigella flexneri strain STEFF_17 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | HUZ45_RS17705 | Protein ID | WP_001263493.1 |
| Coordinates | 3641505..3641903 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | HUZ45_RS17710 | Protein ID | WP_000554757.1 |
| Coordinates | 3641906..3642199 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3637165) | 3637165..3637245 | - | 81 | NuclAT_9 | - | - |
| - (3637165) | 3637165..3637245 | - | 81 | NuclAT_9 | - | - |
| - (3637165) | 3637165..3637245 | - | 81 | NuclAT_9 | - | - |
| - (3637165) | 3637165..3637245 | - | 81 | NuclAT_9 | - | - |
| HUZ45_RS17675 (3636505) | 3636505..3637749 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| HUZ45_RS17680 (3637841) | 3637841..3638299 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| HUZ45_RS17685 (3638560) | 3638560..3640017 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
| HUZ45_RS17690 (3640074) | 3640074..3640595 | - | 522 | Protein_3474 | peptide chain release factor H | - |
| HUZ45_RS17695 (3640594) | 3640594..3640797 | - | 204 | Protein_3475 | RNA ligase RtcB family protein | - |
| HUZ45_RS17700 (3641043) | 3641043..3641495 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| HUZ45_RS17705 (3641505) | 3641505..3641903 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| HUZ45_RS17710 (3641906) | 3641906..3642199 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| HUZ45_RS17715 (3642251) | 3642251..3643306 | - | 1056 | WP_063501914.1 | DNA polymerase IV | - |
| HUZ45_RS17720 (3643377) | 3643377..3644162 | - | 786 | WP_000207564.1 | putative lateral flagellar export/assembly protein LafU | - |
| HUZ45_RS17725 (3644134) | 3644134..3645846 | + | 1713 | Protein_3481 | flagellar biosynthesis protein FlhA | - |
| HUZ45_RS17730 (3646070) | 3646070..3646567 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T161812 WP_001263493.1 NZ_CP055181:c3641903-3641505 [Shigella flexneri]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T161812 NZ_CP071320:c525806-525495 [Serratia ureilytica]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAGTACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCGTCATGA
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAGTACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCGTCATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT161812 WP_000554757.1 NZ_CP055181:c3642199-3641906 [Shigella flexneri]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT161812 NZ_CP071320:c525498-525076 [Serratia ureilytica]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTACCCTTATTGCAGGGCAGCCACGCTCAGCAAGA
CTACCGAGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTCAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCTCCAGCCC
TGTTCCTGCCGGAAGCGGATTAA
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTACCCTTATTGCAGGGCAGCCACGCTCAGCAAGA
CTACCGAGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTCAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCTCCAGCCC
TGTTCCTGCCGGAAGCGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|