Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1796062..1796564 | Replicon | chromosome |
Accession | NZ_CP055181 | ||
Organism | Shigella flexneri strain STEFF_17 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | HUZ45_RS08605 | Protein ID | WP_000767829.1 |
Coordinates | 1796310..1796564 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | HUZ45_RS08600 | Protein ID | WP_001259255.1 |
Coordinates | 1796062..1796313 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUZ45_RS08575 (1791240) | 1791240..1792307 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
HUZ45_RS08580 (1792307) | 1792307..1793377 | - | 1071 | WP_000108940.1 | histidinol-phosphate transaminase | - |
HUZ45_RS08585 (1793374) | 1793374..1794678 | - | 1305 | WP_029402287.1 | histidinol dehydrogenase | - |
HUZ45_RS08590 (1794684) | 1794684..1795583 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
HUZ45_RS08595 (1795729) | 1795729..1795779 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
HUZ45_RS08600 (1796062) | 1796062..1796313 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
HUZ45_RS08605 (1796310) | 1796310..1796564 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
HUZ45_RS08610 (1796647) | 1796647..1797471 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
HUZ45_RS08615 (1797517) | 1797517..1798446 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
HUZ45_RS08620 (1798661) | 1798661..1798723 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
HUZ45_RS08625 (1798713) | 1798713..1800071 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
HUZ45_RS08630 (1800250) | 1800250..1801308 | + | 1059 | WP_000492340.1 | thiosulfate utilization transporter TsuA/YeeE | - |
HUZ45_RS08635 (1801322) | 1801322..1801549 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T161799 WP_000767829.1 NZ_CP055181:1796310-1796564 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T161799 NZ_CP071311:c379025-378756 [Rhizobium sp. X9]
GTGATCTGGACAATTGAGTACCACACACTTGTCCAGAAAGAGATGCGCAAGTTAAATCCGGAAATACGCCGGAGAATCCG
CGCCTTTCTCCACGAAAGATTGGCGGTGCTCGACGATCCCCGTCAGACAGGTTCCGCCCTGCAAGGCTCCGAACTCGGAA
ATTTCTGGCGCTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTTGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGCGAAATTTACCGTTAG
GTGATCTGGACAATTGAGTACCACACACTTGTCCAGAAAGAGATGCGCAAGTTAAATCCGGAAATACGCCGGAGAATCCG
CGCCTTTCTCCACGAAAGATTGGCGGTGCTCGACGATCCCCGTCAGACAGGTTCCGCCCTGCAAGGCTCCGAACTCGGAA
ATTTCTGGCGCTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTTGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGCGAAATTTACCGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT161799 WP_001259255.1 NZ_CP055181:1796062-1796313 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT161799 NZ_CP071311:c379236-379009 [Rhizobium sp. X9]
ATGAGCAAACAGACGGCCATTCGCCTGCCTGATGAGACCTATGAACGGCTGAAAGCGCTGTCCGCGCGCACCGGCCGCAC
ATCCGCTTTTTACATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGATCTCTATCTCGCCGAAGAGGCAGTGC
GACAAATCCAGCGTGGCGAAGCAAAGGTGATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA
ATGAGCAAACAGACGGCCATTCGCCTGCCTGATGAGACCTATGAACGGCTGAAAGCGCTGTCCGCGCGCACCGGCCGCAC
ATCCGCTTTTTACATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGATCTCTATCTCGCCGAAGAGGCAGTGC
GACAAATCCAGCGTGGCGAAGCAAAGGTGATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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