Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 96576..97002 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055180 | ||
| Organism | Shigella flexneri strain STEFF_18 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ46_RS24110 | Protein ID | WP_001372321.1 |
| Coordinates | 96576..96701 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 96778..97002 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ46_RS24070 (91950) | 91950..92639 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ46_RS24075 (92826) | 92826..93209 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ46_RS24080 (93530) | 93530..94132 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ46_RS24085 (94429) | 94429..95250 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ46_RS24090 (95368) | 95368..95655 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ46_RS24095 (95680) | 95680..95886 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ46_RS24100 (95956) | 95956..96128 | + | 173 | Protein_112 | hypothetical protein | - |
| HUZ46_RS24105 (96126) | 96126..96356 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ46_RS24110 (96576) | 96576..96701 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ46_RS24115 (96643) | 96643..96792 | - | 150 | Protein_115 | plasmid maintenance protein Mok | - |
| - (96778) | 96778..97002 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (96778) | 96778..97002 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (96778) | 96778..97002 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (96778) | 96778..97002 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ46_RS24120 (96814) | 96814..97002 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ46_RS24125 (96971) | 96971..97733 | - | 763 | Protein_117 | plasmid SOS inhibition protein A | - |
| HUZ46_RS24130 (97730) | 97730..98164 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ46_RS24135 (98219) | 98219..98416 | - | 198 | Protein_119 | hypothetical protein | - |
| HUZ46_RS24140 (98444) | 98444..98677 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ46_RS24145 (98745) | 98745..99284 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ46_RS24150 (99310) | 99310..99516 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ46_RS24155 (99586) | 99586..99666 | + | 81 | Protein_123 | hypothetical protein | - |
| HUZ46_RS24160 (99849) | 99849..100018 | - | 170 | Protein_124 | hypothetical protein | - |
| HUZ46_RS24165 (100655) | 100655..101626 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-55 / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..122007 | 122007 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161790 WP_001372321.1 NZ_CP055180:c96701-96576 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161790 NZ_CP071282:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 225 bp
>AT161790 NZ_CP055180:c97002-96778 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
