Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1822013..1822515 | Replicon | chromosome |
| Accession | NZ_CP055179 | ||
| Organism | Shigella flexneri strain STEFF_18 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HUZ46_RS08625 | Protein ID | WP_000767829.1 |
| Coordinates | 1822261..1822515 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUZ46_RS08620 | Protein ID | WP_001259255.1 |
| Coordinates | 1822013..1822264 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ46_RS08595 (1817190) | 1817190..1818257 | - | 1068 | WP_000080102.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| HUZ46_RS08600 (1818257) | 1818257..1819327 | - | 1071 | WP_001099214.1 | histidinol-phosphate transaminase | - |
| HUZ46_RS08605 (1819324) | 1819324..1820628 | - | 1305 | WP_001396164.1 | histidinol dehydrogenase | - |
| HUZ46_RS08610 (1820634) | 1820634..1821533 | - | 900 | WP_000566782.1 | ATP phosphoribosyltransferase | - |
| HUZ46_RS08615 (1821679) | 1821679..1821729 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUZ46_RS08620 (1822013) | 1822013..1822264 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUZ46_RS08625 (1822261) | 1822261..1822515 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUZ46_RS08630 (1822598) | 1822598..1823422 | + | 825 | WP_000754754.1 | SDR family oxidoreductase | - |
| HUZ46_RS08635 (1823468) | 1823468..1824397 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| HUZ46_RS08640 (1824612) | 1824612..1824674 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUZ46_RS08645 (1824664) | 1824664..1826022 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUZ46_RS08650 (1826201) | 1826201..1827259 | + | 1059 | WP_000492305.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUZ46_RS08655 (1827273) | 1827273..1827500 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T161767 WP_000767829.1 NZ_CP055179:1822261-1822515 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T161767 NZ_CP071265:c1186532-1186203 [Citrobacter freundii]
ATGAAAACCTTACCTGCAATAGCTCAGCGGGCGGCGAAGACATGCCCGCCACCCGTCGTGATCTGGCAGACATTACTGGC
CCGTCTGTTGGAGACACACTATGGCCTGACGCTCCCCGACACACCGTTCAGTGATGAAACCCTCATTCAGGAACATATCG
ACGCAGGTATCTCTCTGGCCGATGCTGTTAATTTCCTGGTTGAGAAATACGAACTGGTCCGTATCGACCGAAAAGGATTT
TCGTGGCAAGAACAGACTCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
CGTGAAATGA
ATGAAAACCTTACCTGCAATAGCTCAGCGGGCGGCGAAGACATGCCCGCCACCCGTCGTGATCTGGCAGACATTACTGGC
CCGTCTGTTGGAGACACACTATGGCCTGACGCTCCCCGACACACCGTTCAGTGATGAAACCCTCATTCAGGAACATATCG
ACGCAGGTATCTCTCTGGCCGATGCTGTTAATTTCCTGGTTGAGAAATACGAACTGGTCCGTATCGACCGAAAAGGATTT
TCGTGGCAAGAACAGACTCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
CGTGAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT161767 WP_001259255.1 NZ_CP055179:1822013-1822264 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT161767 NZ_CP071265:c1186875-1186558 [Citrobacter freundii]
ATGAGCAACATCACATGGGGTCTGCAGCGGGATATCACTCCGCGTCTGGGGGCCCGTCTGGTACAGGAGGGGAACCAGTT
GCACTATCTGGCTGACCGGGGCAGCATCACCGGTAAATTCAGTAACGCCGAATGCCTGAAGCTGGATGAAGCATTTCCGC
TGTTTATCAGACAGATGGAGTCAATTCTGACCACCGGTGAACTGAATCCTCGCCATTCACACTGCATCGCCCTGTATCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTTCACACGGTTACGTCTATATCGTCATTTATCCTACGCAACCCTAA
ATGAGCAACATCACATGGGGTCTGCAGCGGGATATCACTCCGCGTCTGGGGGCCCGTCTGGTACAGGAGGGGAACCAGTT
GCACTATCTGGCTGACCGGGGCAGCATCACCGGTAAATTCAGTAACGCCGAATGCCTGAAGCTGGATGAAGCATTTCCGC
TGTTTATCAGACAGATGGAGTCAATTCTGACCACCGGTGAACTGAATCCTCGCCATTCACACTGCATCGCCCTGTATCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTTCACACGGTTACGTCTATATCGTCATTTATCCTACGCAACCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|