Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 716321..717096 Replicon chromosome
Accession NZ_CP055174
Organism Klebsiella pneumoniae strain STEFF_19

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag HUZ47_RS03545 Protein ID WP_004889762.1
Coordinates 716611..717096 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HUZ47_RS03540 Protein ID WP_004150912.1
Coordinates 716321..716614 (+) Length 98 a.a.

Genomic Context

HUZ47_RS03525HUZ47_RS03540HUZ47_RS03545HUZ47_RS03550HUZ47_RS03555HUZ47_RS03520HUZ47_RS03530HUZ47_RS03535HUZ47_RS03565
Location: 712230..713141 (912 bp)
Type: Others
Protein ID: WP_017879796.1
Location: 716321..716614 (294 bp)
Type: Antitoxin
Protein ID: WP_004150912.1
Location: 716611..717096 (486 bp)
Type: Toxin
Protein ID: WP_004889762.1
Location: 717800..718392 (593 bp)
Type: Others
Protein ID: Protein_698
Location: 718489..718705 (217 bp)
Type: Others
Protein ID: Protein_699
Location: 711530..712132 (603 bp)
Type: Others
Protein ID: WP_004174410.1
Location: 713142..714290 (1149 bp)
Type: Others
Protein ID: WP_004889759.1
Location: 714301..715677 (1377 bp)
Type: Others
Protein ID: WP_017879795.1
Location: 719220..719933 (714 bp)
Type: Others
Protein ID: WP_002916694.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUZ47_RS03520 (HUZ47_03515)711530..712132-603WP_004174410.1short chain dehydrogenase-
HUZ47_RS03525 (HUZ47_03520)712230..713141+912WP_017879796.1LysR family transcriptional regulator-
HUZ47_RS03530 (HUZ47_03525)713142..714290-1149WP_004889759.1PLP-dependent aspartate aminotransferase family protein-
HUZ47_RS03535 (HUZ47_03530)714301..715677-1377WP_017879795.1pyridoxal-phosphate dependent enzyme-
HUZ47_RS03540 (HUZ47_03535)716321..716614+294WP_004150912.1DUF1778 domain-containing proteinAntitoxin
HUZ47_RS03545 (HUZ47_03540)716611..717096+486WP_004889762.1GNAT family N-acetyltransferaseToxin
HUZ47_RS03550 (HUZ47_03545)717800..718392+593Protein_698hypothetical protein-
HUZ47_RS03555 (HUZ47_03550)718489..718705+217Protein_699transposase-
HUZ47_RS03565 (HUZ47_03560)719220..719933-714WP_002916694.1DUF554 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--718489..718641152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T161739 WP_004889762.1 NZ_CP055174:716611-717096 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

>T161739 NZ_CP071261:c5184973-5184590 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT161739 WP_004150912.1 NZ_CP055174:716321-716614 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT161739 NZ_CP071261:c5185215-5184973 [Klebsiella pneumoniae]
ATGATGGCTGAAAAGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A447W563

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0H3GVL4

References