Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 99723..100149 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055168 | ||
| Organism | Shigella flexneri strain STEFF_24 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ50_RS24130 | Protein ID | WP_001372321.1 |
| Coordinates | 99723..99848 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 99925..100149 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ50_RS24090 (95097) | 95097..95786 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ50_RS24095 (95973) | 95973..96356 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ50_RS24100 (96677) | 96677..97279 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ50_RS24105 (97576) | 97576..98397 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ50_RS24110 (98515) | 98515..98802 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ50_RS24115 (98827) | 98827..99033 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ50_RS24120 (99103) | 99103..99275 | + | 173 | Protein_116 | hypothetical protein | - |
| HUZ50_RS24125 (99273) | 99273..99503 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ50_RS24130 (99723) | 99723..99848 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ50_RS24135 (99790) | 99790..99939 | - | 150 | Protein_119 | plasmid maintenance protein Mok | - |
| - (99925) | 99925..100149 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99925) | 99925..100149 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99925) | 99925..100149 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99925) | 99925..100149 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ50_RS24140 (99961) | 99961..100149 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ50_RS24145 (100118) | 100118..100880 | - | 763 | Protein_121 | plasmid SOS inhibition protein A | - |
| HUZ50_RS24150 (100877) | 100877..101311 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ50_RS24155 (101366) | 101366..101563 | - | 198 | Protein_123 | hypothetical protein | - |
| HUZ50_RS24160 (101591) | 101591..101824 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ50_RS24165 (101892) | 101892..102431 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ50_RS24170 (102457) | 102457..102663 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ50_RS24175 (102733) | 102733..102813 | + | 81 | Protein_127 | hypothetical protein | - |
| HUZ50_RS24180 (102996) | 102996..103165 | - | 170 | Protein_128 | hypothetical protein | - |
| HUZ50_RS24185 (103759) | 103759..104730 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaCTX-M-15 / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..125110 | 125110 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161700 WP_001372321.1 NZ_CP055168:c99848-99723 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161700 NZ_CP071252:c4699500-4698967 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 225 bp
>AT161700 NZ_CP055168:c100149-99925 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
