Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1839460..1840120 Replicon chromosome
Accession NZ_CP055161
Organism Serratia marcescens strain JW-CZ2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HUW55_RS08585 Protein ID WP_049298854.1
Coordinates 1839460..1839813 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag HUW55_RS08590 Protein ID WP_016927038.1
Coordinates 1839818..1840120 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW55_RS08565 1835549..1835914 + 366 WP_004935528.1 diacylglycerol kinase -
HUW55_RS08570 1836018..1836917 + 900 WP_176062918.1 LysR family transcriptional regulator -
HUW55_RS08575 1836892..1837698 - 807 WP_049298855.1 substrate-binding domain-containing protein -
HUW55_RS08580 1837726..1839021 - 1296 WP_028127724.1 MFS transporter -
HUW55_RS08585 1839460..1839813 + 354 WP_049298854.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUW55_RS08590 1839818..1840120 + 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
HUW55_RS08595 1840535..1841743 + 1209 WP_079449935.1 aldose 1-epimerase family protein -
HUW55_RS08605 1842348..1843466 + 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
HUW55_RS08610 1843590..1844504 + 915 WP_016927041.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13486.38 Da        Isoelectric Point: 9.4805

>T161639 WP_049298854.1 NZ_CP055161:1839460-1839813 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQRRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T161639 NZ_CP071236:c4165699-4165277 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT161639 WP_016927038.1 NZ_CP055161:1839818-1840120 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT161639 NZ_CP071236:c4165946-4165680 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References