Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 106281..106707 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055114 | ||
| Organism | Shigella flexneri strain SWHIN_101 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ81_RS24595 | Protein ID | WP_001372321.1 |
| Coordinates | 106281..106406 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 106483..106707 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ81_RS24555 (101655) | 101655..102344 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ81_RS24560 (102531) | 102531..102914 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ81_RS24565 (103235) | 103235..103837 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ81_RS24570 (104134) | 104134..104955 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ81_RS24575 (105073) | 105073..105360 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ81_RS24580 (105385) | 105385..105591 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ81_RS24585 (105661) | 105661..105833 | + | 173 | Protein_118 | hypothetical protein | - |
| HUZ81_RS24590 (105831) | 105831..106061 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ81_RS24595 (106281) | 106281..106406 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ81_RS24600 (106348) | 106348..106497 | - | 150 | Protein_121 | plasmid maintenance protein Mok | - |
| - (106483) | 106483..106707 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (106483) | 106483..106707 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (106483) | 106483..106707 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (106483) | 106483..106707 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ81_RS24605 (106519) | 106519..106707 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ81_RS24610 (106676) | 106676..107438 | - | 763 | Protein_123 | plasmid SOS inhibition protein A | - |
| HUZ81_RS24615 (107435) | 107435..107869 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ81_RS24620 (107924) | 107924..108121 | - | 198 | Protein_125 | hypothetical protein | - |
| HUZ81_RS24625 (108149) | 108149..108382 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ81_RS24630 (108450) | 108450..108989 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ81_RS24635 (109015) | 109015..109221 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ81_RS24640 (109291) | 109291..109371 | + | 81 | Protein_129 | hypothetical protein | - |
| HUZ81_RS24645 (109554) | 109554..109723 | - | 170 | Protein_130 | hypothetical protein | - |
| HUZ81_RS24650 (110360) | 110360..111331 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | oqxA / oqxB / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / sitABCD | iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA | 1..131712 | 131712 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161608 WP_001372321.1 NZ_CP055114:c106406-106281 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161608 NZ_CP071230:1601798-1602106 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA
Antitoxin
Download Length: 225 bp
>AT161608 NZ_CP055114:c106707-106483 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
