Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 77097..77351 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055114 | ||
| Organism | Shigella flexneri strain SWHIN_101 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | HUZ81_RS24410 | Protein ID | WP_001312851.1 |
| Coordinates | 77097..77246 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 77290..77351 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ81_RS24360 (72660) | 72660..73061 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| HUZ81_RS24365 (72994) | 72994..73251 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| HUZ81_RS24370 (73344) | 73344..73601 | - | 258 | WP_230133887.1 | CPBP family intramembrane metalloprotease | - |
| HUZ81_RS24375 (73594) | 73594..73986 | - | 393 | WP_000616804.1 | histidine phosphatase family protein | - |
| HUZ81_RS24380 (74084) | 74084..74224 | - | 141 | WP_001333237.1 | hypothetical protein | - |
| HUZ81_RS24385 (74925) | 74925..75782 | - | 858 | WP_239622796.1 | incFII family plasmid replication initiator RepA | - |
| HUZ81_RS24390 (75775) | 75775..76257 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| HUZ81_RS24395 (76250) | 76250..76297 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| HUZ81_RS24400 (76288) | 76288..76539 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| HUZ81_RS24405 (76556) | 76556..76813 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| HUZ81_RS24410 (77097) | 77097..77246 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (77290) | 77290..77351 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (77290) | 77290..77351 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (77290) | 77290..77351 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (77290) | 77290..77351 | + | 62 | NuclAT_1 | - | Antitoxin |
| HUZ81_RS24415 (77607) | 77607..77681 | - | 75 | Protein_84 | endonuclease | - |
| HUZ81_RS24420 (77927) | 77927..78139 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| HUZ81_RS24425 (78275) | 78275..78835 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| HUZ81_RS24430 (78938) | 78938..79798 | - | 861 | WP_000704514.1 | alpha/beta hydrolase | - |
| HUZ81_RS24435 (79857) | 79857..80603 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | oqxA / oqxB / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / sitABCD | iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA | 1..131712 | 131712 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T161603 WP_001312851.1 NZ_CP055114:c77246-77097 [Shigella flexneri]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T161603 NZ_CP071228:c4164422-4164000 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA
Antitoxin
Download Length: 62 bp
>AT161603 NZ_CP055114:77290-77351 [Shigella flexneri]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
