Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 151907..152333 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055110 | ||
| Organism | Shigella flexneri strain SWHIN_104 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ82_RS23995 | Protein ID | WP_001372321.1 |
| Coordinates | 151907..152032 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 152109..152333 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ82_RS23955 (147281) | 147281..147970 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ82_RS23960 (148157) | 148157..148540 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ82_RS23965 (148861) | 148861..149463 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ82_RS23970 (149760) | 149760..150581 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ82_RS23975 (150699) | 150699..150986 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ82_RS23980 (151011) | 151011..151217 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ82_RS23985 (151287) | 151287..151459 | + | 173 | Protein_170 | hypothetical protein | - |
| HUZ82_RS23990 (151457) | 151457..151687 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ82_RS23995 (151907) | 151907..152032 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ82_RS24000 (151974) | 151974..152123 | - | 150 | Protein_173 | plasmid maintenance protein Mok | - |
| - (152109) | 152109..152333 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (152109) | 152109..152333 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (152109) | 152109..152333 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (152109) | 152109..152333 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ82_RS24005 (152145) | 152145..152333 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ82_RS24010 (152302) | 152302..153064 | - | 763 | Protein_175 | plasmid SOS inhibition protein A | - |
| HUZ82_RS24015 (153061) | 153061..153495 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ82_RS24020 (153550) | 153550..153747 | - | 198 | Protein_177 | hypothetical protein | - |
| HUZ82_RS24025 (153775) | 153775..154008 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ82_RS24030 (154076) | 154076..154615 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ82_RS24035 (154641) | 154641..154847 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ82_RS24040 (154917) | 154917..154997 | + | 81 | Protein_181 | hypothetical protein | - |
| HUZ82_RS24045 (155180) | 155180..155349 | - | 170 | Protein_182 | hypothetical protein | - |
| HUZ82_RS24050 (155728) | 155728..156699 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(A) / oqxA / oqxB / sul2 / aph(3'')-Ib / aph(6)-Id / floR / blaCTX-M-55 / blaTEM-1B / fosA3 / dfrA14 / dfrA12 / aadA2 / mph(A) / aph(3')-Ia / aac(3)-IId / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..177080 | 177080 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161571 WP_001372321.1 NZ_CP055110:c152032-151907 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161571 NZ_CP071222:c1108033-1107830 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
Antitoxin
Download Length: 225 bp
>AT161571 NZ_CP055110:c152333-152109 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
