Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 218081..218934 Replicon plasmid unnamed1
Accession NZ_CP055107
Organism Klebsiella pneumoniae strain SWHIN_106

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HUZ83_RS26500 Protein ID WP_239612463.1
Coordinates 218081..218569 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HUZ83_RS26505 Protein ID WP_239612464.1
Coordinates 218593..218934 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ83_RS26470 (HUZ83_26395) 213086..214195 - 1110 WP_239612458.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
HUZ83_RS26475 (HUZ83_26400) 214188..214646 - 459 WP_239612459.1 NUDIX domain-containing protein -
HUZ83_RS26480 (HUZ83_26405) 214647..215498 - 852 WP_239612460.1 DMT family transporter -
HUZ83_RS26485 (HUZ83_26410) 215502..216572 - 1071 WP_239612461.1 hypothetical protein -
HUZ83_RS26490 (HUZ83_26415) 216846..217191 + 346 Protein_227 transposase -
HUZ83_RS26495 (HUZ83_26420) 217388..217720 - 333 WP_239612462.1 IS200/IS605 family transposase -
HUZ83_RS26500 (HUZ83_26425) 218081..218569 - 489 WP_239612463.1 type II toxin-antitoxin system YhaV family toxin Toxin
HUZ83_RS26505 (HUZ83_26430) 218593..218934 - 342 WP_239612464.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HUZ83_RS26510 (HUZ83_26435) 219692..220027 + 336 WP_239612465.1 hypothetical protein -
HUZ83_RS26515 (HUZ83_26440) 220242..220487 + 246 WP_239612466.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HUZ83_RS26520 (HUZ83_26445) 220487..220819 + 333 WP_239612467.1 endoribonuclease MazF -
HUZ83_RS26525 (HUZ83_26450) 221481..221948 + 468 WP_124737156.1 hypothetical protein -
HUZ83_RS26530 (HUZ83_26455) 221993..222199 - 207 WP_063938351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..301800 301800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(15-112)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18741.47 Da        Isoelectric Point: 6.7184

>T161542 WP_239612463.1 NZ_CP055107:c218569-218081 [Klebsiella pneumoniae]
MDNLELNGWKIYFHSCFLNQIVELAQKVADLKATKPDEYQTRKEAKLLLAIERVIEEWIVADPLNPQYRQGDTLGGEYKH
WFRAKFLAQFRLFYRCSEEHKTIIIGWVNDFGTLRAYGSKTDAYLVFAKMLKAGEPPDDWEKLLTEARASTATATVSGFL
EK

Download         Length: 489 bp

>T161542 NZ_CP071214:4534583-4534894 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCATTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12456.18 Da        Isoelectric Point: 4.4346

>AT161542 WP_239612464.1 NZ_CP055107:c218934-218593 [Klebsiella pneumoniae]
MAKTLDSASVSLRAESRLTERSQTTIPAVIRDALHLKPGEYINYTLLAGGKVIMSRQEEEQDDPVVSKFLSFIEDDMKKN
PQNIAPVPVVFWEGIKALTAGVEVDLDAPLTDN

Download         Length: 342 bp

>AT161542 NZ_CP071214:4534891-4535313 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTTGAATTGGTGGAATACCTGCTGGAAAACGACGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGTAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References