Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 43793..44057 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP055101 | ||
| Organism | Shigella flexneri strain SWHIN_107 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | HUZ84_RS24575 | Protein ID | WP_001331364.1 |
| Coordinates | 43905..44057 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 43793..43850 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ84_RS24560 (40131) | 40131..41201 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| HUZ84_RS24565 (41220) | 41220..42428 | - | 1209 | WP_001383960.1 | IncI1-type conjugal transfer protein TrbA | - |
| HUZ84_RS24570 (42646) | 42646..43599 | - | 954 | WP_021513958.1 | hypothetical protein | - |
| - (43793) | 43793..43850 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (43793) | 43793..43850 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (43793) | 43793..43850 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (43793) | 43793..43850 | - | 58 | NuclAT_0 | - | Antitoxin |
| HUZ84_RS24575 (43905) | 43905..44057 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| HUZ84_RS24580 (44129) | 44129..44380 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| HUZ84_RS25515 (44879) | 44879..44974 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| HUZ84_RS24590 (45039) | 45039..45215 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| HUZ84_RS24595 (45547) | 45547..45756 | + | 210 | WP_000062602.1 | HEAT repeat domain-containing protein | - |
| HUZ84_RS24600 (45828) | 45828..46490 | - | 663 | WP_000644792.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| HUZ84_RS24605 (46555) | 46555..48723 | - | 2169 | WP_077250315.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..88969 | 88969 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T161516 WP_001331364.1 NZ_CP055101:43905-44057 [Shigella flexneri]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T161516 NZ_CP071210:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
Antitoxin
Download Length: 58 bp
>AT161516 NZ_CP055101:c43850-43793 [Shigella flexneri]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
