Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 146443..146869 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055100 | ||
| Organism | Shigella flexneri strain SWHIN_107 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | HUZ84_RS24160 | Protein ID | WP_001372321.1 |
| Coordinates | 146443..146568 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 146645..146869 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ84_RS24120 (141817) | 141817..142506 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| HUZ84_RS24125 (142693) | 142693..143076 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HUZ84_RS24130 (143397) | 143397..143999 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| HUZ84_RS24135 (144296) | 144296..145117 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| HUZ84_RS24140 (145235) | 145235..145522 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HUZ84_RS24145 (145547) | 145547..145753 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| HUZ84_RS24150 (145823) | 145823..145995 | + | 173 | Protein_165 | hypothetical protein | - |
| HUZ84_RS24155 (145993) | 145993..146223 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| HUZ84_RS24160 (146443) | 146443..146568 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| HUZ84_RS24165 (146510) | 146510..146659 | - | 150 | Protein_168 | plasmid maintenance protein Mok | - |
| - (146645) | 146645..146869 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (146645) | 146645..146869 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (146645) | 146645..146869 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (146645) | 146645..146869 | - | 225 | NuclAT_0 | - | Antitoxin |
| HUZ84_RS24170 (146681) | 146681..146869 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| HUZ84_RS24175 (146838) | 146838..147600 | - | 763 | Protein_170 | plasmid SOS inhibition protein A | - |
| HUZ84_RS24180 (147597) | 147597..148031 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| HUZ84_RS24185 (148086) | 148086..148283 | - | 198 | Protein_172 | hypothetical protein | - |
| HUZ84_RS24190 (148311) | 148311..148544 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| HUZ84_RS24195 (148612) | 148612..149151 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| HUZ84_RS24200 (149177) | 149177..149383 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| HUZ84_RS24205 (149453) | 149453..149533 | + | 81 | Protein_176 | hypothetical protein | - |
| HUZ84_RS24210 (149716) | 149716..149885 | - | 170 | Protein_177 | hypothetical protein | - |
| HUZ84_RS24215 (150522) | 150522..151493 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | oqxA / oqxB / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaCTX-M-55 / blaTEM-1B / fosA3 / dfrA14 / dfrA12 / aadA2 / mph(A) / aph(3')-Ia / aac(3)-IId / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..171874 | 171874 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T161512 WP_001372321.1 NZ_CP055100:c146568-146443 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T161512 NZ_CP071208:c3786713-3786324 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
Antitoxin
Download Length: 225 bp
>AT161512 NZ_CP055100:c146869-146645 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
