Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4872219..4872973 | Replicon | chromosome |
| Accession | NZ_CP055089 | ||
| Organism | Citrobacter portucalensis strain SWHIN_111 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5B0T5Y1 |
| Locus tag | HUZ88_RS23465 | Protein ID | WP_048215202.1 |
| Coordinates | 4872219..4872530 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HUZ88_RS23470 | Protein ID | WP_048215203.1 |
| Coordinates | 4872527..4872973 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ88_RS23435 (HUZ88_23380) | 4867881..4868783 | + | 903 | WP_003825273.1 | formate dehydrogenase O subunit beta | - |
| HUZ88_RS23440 (HUZ88_23385) | 4868780..4869415 | + | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
| HUZ88_RS23445 (HUZ88_23390) | 4869412..4870341 | + | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
| HUZ88_RS23450 (HUZ88_23395) | 4870385..4870672 | - | 288 | WP_038635893.1 | NadS family protein | - |
| HUZ88_RS23455 (HUZ88_23400) | 4870673..4870984 | - | 312 | WP_103015341.1 | toxin HigB-2 | - |
| HUZ88_RS23460 (HUZ88_23405) | 4871205..4872134 | + | 930 | WP_239605720.1 | alpha/beta hydrolase | - |
| HUZ88_RS23465 (HUZ88_23410) | 4872219..4872530 | + | 312 | WP_048215202.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| HUZ88_RS23470 (HUZ88_23415) | 4872527..4872973 | + | 447 | WP_048215203.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HUZ88_RS23475 (HUZ88_23420) | 4872991..4873932 | - | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
| HUZ88_RS23480 (HUZ88_23425) | 4873977..4874414 | - | 438 | WP_003825289.1 | D-aminoacyl-tRNA deacylase | - |
| HUZ88_RS23485 (HUZ88_23430) | 4874411..4875283 | - | 873 | WP_008786998.1 | virulence factor BrkB family protein | - |
| HUZ88_RS23490 (HUZ88_23435) | 4875277..4875876 | - | 600 | WP_008786997.1 | glucose-1-phosphatase | - |
| HUZ88_RS23495 (HUZ88_23440) | 4875982..4876785 | - | 804 | WP_060683040.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| HUZ88_RS23500 (HUZ88_23445) | 4876819..4877715 | - | 897 | WP_239605721.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12345.28 Da Isoelectric Point: 9.5337
>T161440 WP_048215202.1 NZ_CP055089:4872219-4872530 [Citrobacter portucalensis]
VHVISRKPFNEAMLMYPNHQLALADLLNVLEKKTFIQPEEMKQYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRSHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHQLALADLLNVLEKKTFIQPEEMKQYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRSHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T161440 NZ_CP071192:c3787990-3787601 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16660.97 Da Isoelectric Point: 6.7580
>AT161440 WP_048215203.1 NZ_CP055089:4872527-4872973 [Citrobacter portucalensis]
MRTHRHMDAASAKKIVDTFSDAVKTIPLLGEDRNDTEYRRALALVEYLVDHDDLENPLFELLCARISKYEKHAPEFKALN
QHLEKTPSGVSVLRTLMDQYSLKAADLANELGSKSNVSNILNGRRALTVSHIKALAERFNLPADAFIE
MRTHRHMDAASAKKIVDTFSDAVKTIPLLGEDRNDTEYRRALALVEYLVDHDDLENPLFELLCARISKYEKHAPEFKALN
QHLEKTPSGVSVLRTLMDQYSLKAADLANELGSKSNVSNILNGRRALTVSHIKALAERFNLPADAFIE
Download Length: 447 bp
>AT161440 NZ_CP071192:c3788257-3787994 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|