161422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 342917..343583 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name higB Uniprot ID A0A5B0T6K1
Locus tag HUZ88_RS01585 Protein ID WP_047408175.1
Coordinates 343266..343583 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5B0T6F5
Locus tag HUZ88_RS01580 Protein ID WP_048236945.1
Coordinates 342917..343213 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS01565 (HUZ88_01550) 339362..339835 - 474 WP_003023524.1 transcription elongation factor GreB -
HUZ88_RS01570 (HUZ88_01555) 340061..340780 + 720 WP_001157751.1 two-component system response regulator OmpR -
HUZ88_RS01575 (HUZ88_01560) 340777..342129 + 1353 WP_003827658.1 two-component system sensor histidine kinase EnvZ -
HUZ88_RS01580 (HUZ88_01565) 342917..343213 - 297 WP_048236945.1 NadS family protein Antitoxin
HUZ88_RS01585 (HUZ88_01570) 343266..343583 - 318 WP_047408175.1 toxin HigB-2 Toxin
HUZ88_RS01590 (HUZ88_01575) 343706..345328 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
HUZ88_RS01595 (HUZ88_01580) 345707..347425 + 1719 WP_239605849.1 DUF4153 domain-containing protein -
HUZ88_RS01600 (HUZ88_01585) 347535..348413 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12255.17 Da        Isoelectric Point: 10.0909

>T161422 WP_047408175.1 NZ_CP055089:c343583-343266 [Citrobacter portucalensis]
MFTFIELQGFSKRRPLLLPDDEFRAFQETLIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

>T161422 NZ_CP071188:c3786720-3786331 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11185.95 Da        Isoelectric Point: 7.2052

>AT161422 WP_048236945.1 NZ_CP055089:c343213-342917 [Citrobacter portucalensis]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQRNPFIINQLKAI

Download         Length: 297 bp

>AT161422 NZ_CP071188:c3786987-3786724 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T6K1

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0T6F5

References