Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1806745..1807247 | Replicon | chromosome |
| Accession | NZ_CP055075 | ||
| Organism | Shigella flexneri strain SWHIN_116 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HUZ90_RS08555 | Protein ID | WP_000767829.1 |
| Coordinates | 1806993..1807247 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUZ90_RS08550 | Protein ID | WP_001259255.1 |
| Coordinates | 1806745..1806996 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ90_RS08525 (1801922) | 1801922..1802989 | - | 1068 | WP_074579688.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| HUZ90_RS08530 (1802989) | 1802989..1804059 | - | 1071 | WP_000108945.1 | histidinol-phosphate transaminase | - |
| HUZ90_RS08535 (1804056) | 1804056..1805360 | - | 1305 | WP_087898060.1 | histidinol dehydrogenase | - |
| HUZ90_RS08540 (1805366) | 1805366..1806265 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HUZ90_RS08545 (1806411) | 1806411..1806461 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUZ90_RS08550 (1806745) | 1806745..1806996 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUZ90_RS08555 (1806993) | 1806993..1807247 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUZ90_RS08560 (1807330) | 1807330..1808154 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| HUZ90_RS08565 (1808200) | 1808200..1809129 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| HUZ90_RS08570 (1809344) | 1809344..1809406 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUZ90_RS08575 (1809396) | 1809396..1810754 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUZ90_RS08580 (1810933) | 1810933..1811991 | + | 1059 | WP_000492330.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUZ90_RS08585 (1812005) | 1812005..1812232 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T161375 WP_000767829.1 NZ_CP055075:1806993-1807247 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T161375 NZ_CP071144:c980059-979721 [Streptococcus equi subsp. equi]
ATGGCTTATGATATCTATATTTCAAATAAGGCAGAACAAGATTTAGATGAAATCTATAACTACTATTTAACAGAATTTTC
GCACTCAAGCGCTCAAAAAGTTATTGAATCTTTGCAGTCAGCTATTTCTATTCTTGAGATATCCCCTGAAGGTTATGTTG
ATTTTGACGATCGTGTAGGACGTAAACTATTTCCTGAAGGCCAGCTAAGGATGATTCCTAGTAAGCATTTCATAGTATTT
TATTTAATTCGTCAGTCAAGGGTAGATATTCTTCGTATTAGAAGTACTAAAACTGATTATTTAAATGATTTAGAGAATCT
TTTTAACAATATCCTTTAA
ATGGCTTATGATATCTATATTTCAAATAAGGCAGAACAAGATTTAGATGAAATCTATAACTACTATTTAACAGAATTTTC
GCACTCAAGCGCTCAAAAAGTTATTGAATCTTTGCAGTCAGCTATTTCTATTCTTGAGATATCCCCTGAAGGTTATGTTG
ATTTTGACGATCGTGTAGGACGTAAACTATTTCCTGAAGGCCAGCTAAGGATGATTCCTAGTAAGCATTTCATAGTATTT
TATTTAATTCGTCAGTCAAGGGTAGATATTCTTCGTATTAGAAGTACTAAAACTGATTATTTAAATGATTTAGAGAATCT
TTTTAACAATATCCTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT161375 WP_001259255.1 NZ_CP055075:1806745-1806996 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT161375 NZ_CP071144:c980336-980049 [Streptococcus equi subsp. equi]
ATGGCTACATTAATAAGAGATAGACAGTATAATTTTAGAGTAAATACGGAAATGATGGAAGAAGCAAAGCGTATTTTAGA
AGCTAAAAATATTAGTGTTCCAGATGCTCTTAATCTATTTGTTGAACGGGTGGTGGAAGAAAAAGATTTACCTATTAAAA
CTGCAGAACAAATTAGAGCTGAATCATTTTTAAATGAACTGATATCAGAGCTTGATGAAGGGTATCAAGATATTTTAGCA
GGACGTACGAAGCCAGCTAATGAGGTATTTTCAAAATATGGCTTATGA
ATGGCTACATTAATAAGAGATAGACAGTATAATTTTAGAGTAAATACGGAAATGATGGAAGAAGCAAAGCGTATTTTAGA
AGCTAAAAATATTAGTGTTCCAGATGCTCTTAATCTATTTGTTGAACGGGTGGTGGAAGAAAAAGATTTACCTATTAAAA
CTGCAGAACAAATTAGAGCTGAATCATTTTTAAATGAACTGATATCAGAGCTTGATGAAGGGTATCAAGATATTTTAGCA
GGACGTACGAAGCCAGCTAATGAGGTATTTTCAAAATATGGCTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|