Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 655742..656469 Replicon chromosome
Accession NZ_CP055075
Organism Shigella flexneri strain SWHIN_116

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag HUZ90_RS03205 Protein ID WP_000550189.1
Coordinates 655742..656056 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HUZ90_RS03210 Protein ID WP_000560255.1
Coordinates 656053..656469 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ90_RS03185 (651908) 651908..652894 - 987 WP_053274491.1 Gfo/Idh/MocA family oxidoreductase -
HUZ90_RS03190 (652973) 652973..653656 - 684 WP_001183041.1 vancomycin high temperature exclusion protein -
HUZ90_RS03195 (653733) 653733..654236 - 504 WP_001295542.1 M48 family metallopeptidase -
HUZ90_RS03200 (654321) 654321..655457 + 1137 WP_000018690.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
HUZ90_RS03205 (655742) 655742..656056 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
HUZ90_RS03210 (656053) 656053..656469 + 417 WP_000560255.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
HUZ90_RS03215 (656514) 656514..658532 - 2019 WP_047632951.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
HUZ90_RS03220 (658858) 658858..661209 - 2352 WP_134778504.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T161371 WP_000550189.1 NZ_CP055075:655742-656056 [Shigella flexneri]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T161371 NZ_CP071142:931745-932083 [Streptococcus equi subsp. equi]
ATGGCTTATGATATCTATATTTCAAATAAGGCAGAACAAGATTTAGATGAAATCTATAACTACTATTTAACAGAATTTTC
GCACTCAAGCGCTCAAAAAGTTATTGAATCTTTGCAGTCAGCTATTTCTATTCTTGAGATATCCCCTGAAGGTTATGTTG
ATTTTGACGATCGTGTAGGACGTAAACTATTTCCTGAAGGCCAGCTAAGGATGATTCCTAGTAAGCATTTCATAGTATTT
TATTTAATTCGTCAGTCAAGGGTAGATATTCTTCGTATTAGAAGTACTAAAACTGATTATTTAAATGATTTAGAGAATCT
TTTTAACAATATCCTTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14951.41 Da        Isoelectric Point: 4.5577

>AT161371 WP_000560255.1 NZ_CP055075:656053-656469 [Shigella flexneri]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT161371 NZ_CP071142:931468-931755 [Streptococcus equi subsp. equi]
ATGGCTACATTAATAAGAGATAGACAGTATAATTTTAGAGTAAATACGGAAATGATGGAAGAAGCAAAGCGTATTTTAGA
AGCTAAAAATATTAGTGTTCCAGATGCTCTTAATCTATTTGTTGAACGGGTGGTGGAAGAAAAAGATTTACCTATTAAAA
CTGCAGAACAAATTAGAGCTGAATCATTTTTAAATGAACTGATATCAGAGCTTGATGAAGGGTATCAAGATATTTTAGCA
GGACGTACGAAGCCAGCTAATGAGGTATTTTCAAAATATGGCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References