Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 143198..143452 Replicon plasmid unnamed1
Accession NZ_CP055071
Organism Shigella flexneri strain SWHIN_97

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag HUZ91_RS24065 Protein ID WP_001312851.1
Coordinates 143303..143452 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 143198..143259 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ91_RS24050 (141151) 141151..141894 + 744 WP_039002216.1 conjugal transfer pilus acetylase TraX -
HUZ91_RS24055 (141949) 141949..142509 + 561 WP_000139310.1 fertility inhibition protein FinO -
HUZ91_RS24060 (142644) 142644..142856 + 213 WP_001541896.1 ANR family transcriptional regulator -
- (143198) 143198..143259 - 62 NuclAT_1 - Antitoxin
- (143198) 143198..143259 - 62 NuclAT_1 - Antitoxin
- (143198) 143198..143259 - 62 NuclAT_1 - Antitoxin
- (143198) 143198..143259 - 62 NuclAT_1 - Antitoxin
HUZ91_RS24065 (143303) 143303..143452 + 150 WP_001312851.1 Hok/Gef family protein Toxin
HUZ91_RS24070 (143720) 143720..143977 + 258 WP_001541895.1 replication regulatory protein RepA -
HUZ91_RS24075 (144080) 144080..144263 + 184 Protein_161 plasmid copy control protein CopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxA / oqxB / qnrS1 / sul3 - 1..144275 144275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T161367 WP_001312851.1 NZ_CP055071:143303-143452 [Shigella flexneri]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T161367 NZ_CP071138:1180831-1180938 [Mammaliicoccus sciuri]
ATGGTTCAAGATCTAGAAGATGTTAAAGAACTAGGTAAAGAAATGGAACAAATATCAGAACAAAATGATGAGGCTTTTGA
AGAAAAGAAATCTGAACAAGAATCTTAA

Antitoxin


Download         Length: 62 bp

>AT161367 NZ_CP055071:c143259-143198 [Shigella flexneri]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References