Detailed information of TA system TA161364

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 107883..108152
• Replicon: plasmid unnamed1
• Accession: NZ_CP055071
• Organism: Shigella flexneri strain SWHIN_97

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HUZ91_RS23870
• Protein ID: WP_001372321.1
• Coordinates: 108027..108152 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	107883..107948 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ91_RS23825	102957..103184	+	228	WP_071961421.1	hypothetical protein	-
HUZ91_RS23830	103425..103631	+	207	WP_000275853.1	hypothetical protein	-
HUZ91_RS23835	103657..104196	+	540	WP_032332913.1	single-stranded DNA-binding protein	-
HUZ91_RS23840	104253..104486	+	234	WP_000005987.1	DUF905 family protein	-
HUZ91_RS23845	104551..106509	+	1959	WP_039000998.1	ParB/RepB/Spo0J family partition protein	-
HUZ91_RS23850	106564..106998	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
HUZ91_RS23855	106995..107714	+	720	WP_001276232.1	plasmid SOS inhibition protein A	-
HUZ91_RS23860	107726..107914	-	189	WP_001299721.1	hypothetical protein	-
-	107726..107950	+	225	NuclAT_0	-	-
-	107726..107950	+	225	NuclAT_0	-	-
-	107726..107950	+	225	NuclAT_0	-	-
-	107726..107950	+	225	NuclAT_0	-	-
-	107883..107948	+	66	-	-	Antitoxin
HUZ91_RS23865	107936..108085	+	150	Protein_119	plasmid maintenance protein Mok	-
HUZ91_RS23870	108027..108152	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HUZ91_RS23875	108372..108602	+	231	WP_001426396.1	hypothetical protein	-
HUZ91_RS23880	108600..108773	-	174	Protein_122	hypothetical protein	-
HUZ91_RS23885	108843..109049	+	207	WP_000547968.1	hypothetical protein	-
HUZ91_RS23890	109074..109361	+	288	WP_000107535.1	hypothetical protein	-
HUZ91_RS23895	109484..110305	+	822	WP_239606300.1	DUF932 domain-containing protein	-
HUZ91_RS23900	110602..111204	-	603	WP_000243712.1	transglycosylase SLT domain-containing protein	-
HUZ91_RS23905	111525..111908	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HUZ91_RS23910	112095..112784	+	690	WP_039002187.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	oqxA / oqxB / qnrS1 / sul3	-	1..144275	144275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T161364 WP_001372321.1 NZ_CP055071:108027-108152 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T161364 NZ_CP071137:2460984-2461382 [Ferrovum myxofaciens]
ATGAAACGATATATGCTCGATACCAACACGGTGAGTCATCTGCTCAAAGCCCATCCGACCGTTGCTCGTCGCATGGTGGA
GGTGCCAATGGCTTCCCTGTCCATCTCGGCCATCACTGAGGGAGAACTTCTTTTTGGCCTGGCGAAGCGACCGGAGGCAA
AGCGGCTCCATACCGCTGTGCGGGAATTTTTACGGCGTGTTGATGTGCTGCCCTGGGACAATGCCATTTCGGAGCGTTAC
GGAACGGTACGGGCCGATATGGAGAAGCAAGGCAATATACTCGCGCCGCTTGATCTGCTGATCGCCGCGCATGCACTCAG
TAAGGGCGCGATATTGGTGACCAATGACCAGGCTTTCGGTCAGGTGGCCAACCTCCTTCTCGAAGATTGGACAAATTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT161364 NZ_CP055071:107883-107948 [Shigella flexneri]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Antitoxin