Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 727779..728472 Replicon chromosome
Accession NZ_CP055070
Organism Shigella flexneri strain SWHIN_97

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ91_RS03595 Protein ID WP_000415584.1
Coordinates 727779..728075 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ91_RS03600 Protein ID WP_000650107.1
Coordinates 728077..728472 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ91_RS03560 (722866) 722866..723180 - 315 WP_000958598.1 putative quinol monooxygenase -
HUZ91_RS03565 (723211) 723211..723792 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUZ91_RS03570 (724111) 724111..724444 + 334 Protein_700 DUF2645 family protein -
HUZ91_RS03575 (724490) 724490..725839 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUZ91_RS03580 (725836) 725836..726495 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ91_RS03585 (726647) 726647..727039 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ91_RS03590 (727092) 727092..727574 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ91_RS03595 (727779) 727779..728075 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ91_RS03600 (728077) 728077..728472 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ91_RS03605 (728605) 728605..730212 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUZ91_RS03610 (730350) 730350..732608 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T161340 WP_000415584.1 NZ_CP055070:727779-728075 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T161340 NZ_CP071128:2868856-2869233 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT161340 WP_000650107.1 NZ_CP055070:728077-728472 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT161340 NZ_CP071128:2868602-2868859 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References