Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4178949..4179748 Replicon chromosome
Accession NZ_CP055055
Organism Shigella dysenteriae strain SWHEFF_49

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HUZ68_RS19905 Protein ID WP_062882798.1
Coordinates 4179284..4179748 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HUZ68_RS19900 Protein ID WP_021568806.1
Coordinates 4178949..4179284 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ68_RS19885 (4174734) 4174734..4175504 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
HUZ68_RS19890 (4175520) 4175520..4176854 - 1335 WP_096840151.1 galactarate/glucarate/glycerate transporter GarP -
HUZ68_RS19895 (4177229) 4177229..4178800 + 1572 WP_096840150.1 galactarate dehydratase -
HUZ68_RS19900 (4178949) 4178949..4179284 + 336 WP_021568806.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUZ68_RS19905 (4179284) 4179284..4179748 + 465 WP_062882798.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUZ68_RS19910 (4179803) 4179803..4180612 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUZ68_RS19915 (4180861) 4180861..4182141 + 1281 WP_239593966.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUZ68_RS19920 (4182164) 4182164..4182637 + 474 WP_001362195.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUZ68_RS19925 (4182648) 4182648..4183427 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
HUZ68_RS19930 (4183417) 4183417..4184295 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
HUZ68_RS19935 (4184313) 4184313..4184747 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4170027..4179748 9721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17852.20 Da        Isoelectric Point: 9.2151

>T161267 WP_062882798.1 NZ_CP055055:4179284-4179748 [Shigella dysenteriae]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFDAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEETH

Download         Length: 465 bp

>T161267 NZ_CP071127:1967913-1968161 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTA
GCCGGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12357.96 Da        Isoelectric Point: 5.1296

>AT161267 WP_021568806.1 NZ_CP055055:4178949-4179284 [Shigella dysenteriae]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGNEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT161267 NZ_CP071127:1967701-1967913 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References