Detailed information of TA system TA161244

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 84230..84656
• Replicon: plasmid unnamed1
• Accession: NZ_CP055053
• Organism: Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HUZ69_RS24670
• Protein ID: WP_001372321.1
• Coordinates: 84230..84355 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	84432..84656 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ69_RS24630 (79597)	79597..80286	-	690	WP_000283383.1	conjugal transfer transcriptional regulator TraJ	-
HUZ69_RS24635 (80479)	80479..80862	-	384	WP_001151522.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HUZ69_RS24640 (81195)	81195..81785	+	591	WP_165835419.1	transglycosylase SLT domain-containing protein	-
HUZ69_RS24645 (82082)	82082..82902	-	821	Protein_86	DUF932 domain-containing protein	-
HUZ69_RS24650 (83021)	83021..83308	-	288	WP_000107535.1	hypothetical protein	-
HUZ69_RS24655 (83333)	83333..83539	-	207	WP_000547968.1	hypothetical protein	-
HUZ69_RS24660 (83609)	83609..83782	+	174	Protein_89	hypothetical protein	-
HUZ69_RS24665 (83780)	83780..84010	-	231	WP_001426396.1	hypothetical protein	-
HUZ69_RS24670 (84230)	84230..84355	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HUZ69_RS24675 (84297)	84297..84446	-	150	Protein_92	plasmid maintenance protein Mok	-
- (84432)	84432..84656	-	225	NuclAT_0	-	Antitoxin
- (84432)	84432..84656	-	225	NuclAT_0	-	Antitoxin
- (84432)	84432..84656	-	225	NuclAT_0	-	Antitoxin
- (84432)	84432..84656	-	225	NuclAT_0	-	Antitoxin
HUZ69_RS24680 (84468)	84468..84656	+	189	WP_001299721.1	hypothetical protein	-
HUZ69_RS24685 (84668)	84668..85387	-	720	WP_239594264.1	plasmid SOS inhibition protein A	-
HUZ69_RS24690 (85384)	85384..85818	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
HUZ69_RS24695 (85873)	85873..87831	-	1959	WP_001775124.1	ParB/RepB/Spo0J family partition protein	-
HUZ69_RS24700 (87897)	87897..88130	-	234	WP_089533205.1	DUF905 family protein	-
HUZ69_RS24705 (88193)	88193..88732	-	540	WP_000290841.1	single-stranded DNA-binding protein	-
HUZ69_RS24710 (88758)	88758..88964	-	207	WP_000275853.1	hypothetical protein	-
HUZ69_RS24715 (89205)	89205..89474	-	270	WP_071977877.1	hypothetical protein	-
HUZ69_RS24720 (89375)	89375..89599	-	225	WP_016238251.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..117256	117256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T161244 WP_001372321.1 NZ_CP055053:c84355-84230 [Shigella dysenteriae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T161244 NZ_CP071127:677921-678328 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Nucleotide

• Length: 225 bp

>AT161244 NZ_CP055053:c84656-84432 [Shigella dysenteriae]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin