Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3939010..3939703 Replicon chromosome
Accession NZ_CP055041
Organism Shigella flexneri strain SWHEFF_59

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ71_RS19220 Protein ID WP_000415584.1
Coordinates 3939407..3939703 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ71_RS19215 Protein ID WP_000650107.1
Coordinates 3939010..3939405 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ71_RS19205 (3934874) 3934874..3937132 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
HUZ71_RS19210 (3937270) 3937270..3938877 - 1608 WP_072644028.1 ABC transporter substrate-binding protein -
HUZ71_RS19215 (3939010) 3939010..3939405 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ71_RS19220 (3939407) 3939407..3939703 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ71_RS19225 (3939908) 3939908..3940390 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ71_RS19230 (3940443) 3940443..3940835 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ71_RS19235 (3940987) 3940987..3941646 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ71_RS19240 (3941643) 3941643..3942992 + 1350 WP_072644029.1 quorum sensing histidine kinase QseC -
HUZ71_RS19245 (3943038) 3943038..3943370 - 333 WP_000917684.1 DUF2645 family protein -
HUZ71_RS19250 (3943689) 3943689..3944270 + 582 WP_001469336.1 NADPH:quinone oxidoreductase MdaB -
HUZ71_RS19255 (3944301) 3944301..3944615 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T161189 WP_000415584.1 NZ_CP055041:c3939703-3939407 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T161189 NZ_CP071086:332933-333301 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGTCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTATAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT161189 WP_000650107.1 NZ_CP055041:c3939405-3939010 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT161189 NZ_CP071086:332715-332936 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGCTCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References