Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717565..718258 Replicon chromosome
Accession NZ_CP055037
Organism Shigella flexneri strain SWHEFF_60

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ72_RS03505 Protein ID WP_000415584.1
Coordinates 717565..717861 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ72_RS03510 Protein ID WP_000650107.1
Coordinates 717863..718258 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ72_RS03470 (712653) 712653..712967 - 315 WP_000958598.1 putative quinol monooxygenase -
HUZ72_RS03475 (712998) 712998..713579 - 582 WP_001569186.1 NADPH:quinone oxidoreductase MdaB -
HUZ72_RS03480 (713898) 713898..714230 + 333 WP_000917684.1 DUF2645 family protein -
HUZ72_RS03485 (714276) 714276..715625 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUZ72_RS03490 (715622) 715622..716281 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ72_RS03495 (716433) 716433..716825 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ72_RS03500 (716878) 716878..717360 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ72_RS03505 (717565) 717565..717861 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ72_RS03510 (717863) 717863..718258 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ72_RS03515 (718391) 718391..719998 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUZ72_RS03520 (720136) 720136..722394 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T161139 WP_000415584.1 NZ_CP055037:717565-717861 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T161139 NZ_CP071063:c2859189-2859086 [Enterobacter mori]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT161139 WP_000650107.1 NZ_CP055037:717863-718258 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT161139 NZ_CP071063:2859081-2859224 [Enterobacter mori]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References