Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1840475..1840977 | Replicon | chromosome |
| Accession | NZ_CP055030 | ||
| Organism | Shigella flexneri strain SWHEFF_64 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HUZ74_RS08750 | Protein ID | WP_000767829.1 |
| Coordinates | 1840723..1840977 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUZ74_RS08745 | Protein ID | WP_001259255.1 |
| Coordinates | 1840475..1840726 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ74_RS08720 (1835653) | 1835653..1836720 | - | 1068 | WP_016232166.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| HUZ74_RS08725 (1836720) | 1836720..1837790 | - | 1071 | WP_239594509.1 | histidinol-phosphate transaminase | - |
| HUZ74_RS08730 (1837787) | 1837787..1839091 | - | 1305 | WP_001298841.1 | histidinol dehydrogenase | - |
| HUZ74_RS08735 (1839097) | 1839097..1839996 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HUZ74_RS08740 (1840142) | 1840142..1840192 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUZ74_RS08745 (1840475) | 1840475..1840726 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUZ74_RS08750 (1840723) | 1840723..1840977 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUZ74_RS08755 (1841060) | 1841060..1841884 | + | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| HUZ74_RS08760 (1841930) | 1841930..1842859 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| HUZ74_RS08765 (1843074) | 1843074..1843136 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUZ74_RS08770 (1843126) | 1843126..1844484 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUZ74_RS08775 (1844663) | 1844663..1845721 | + | 1059 | WP_061350760.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUZ74_RS08780 (1845735) | 1845735..1845962 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T161099 WP_000767829.1 NZ_CP055030:1840723-1840977 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T161099 NZ_CP071026:c14653-14303 [Enterobacter hormaechei]
ATGTGGGCCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACTGATAGAGCCAACGTCCTTGC
TTCGATGATGGTACTTCGTGACAGAGGTCCTATGCTTTCGAGGCCATACGCTGACACTGTGAACGGTTCATCCTACAGCA
ACATGAAAGAGCTACGGGTTCAAAGCAAAGGAGATCCTCTCAGAGCGTTCTTTGCATTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGTGCCGGTAATAAGACTGGGGATGAGAAACGATTTTATGAAGTAATGATCCCAATTGCAGACCGTGAATTTGC
GGCGCACTTGGATAAATTAAAGAAGGAGTAA
ATGTGGGCCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACTGATAGAGCCAACGTCCTTGC
TTCGATGATGGTACTTCGTGACAGAGGTCCTATGCTTTCGAGGCCATACGCTGACACTGTGAACGGTTCATCCTACAGCA
ACATGAAAGAGCTACGGGTTCAAAGCAAAGGAGATCCTCTCAGAGCGTTCTTTGCATTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGTGCCGGTAATAAGACTGGGGATGAGAAACGATTTTATGAAGTAATGATCCCAATTGCAGACCGTGAATTTGC
GGCGCACTTGGATAAATTAAAGAAGGAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT161099 WP_001259255.1 NZ_CP055030:1840475-1840726 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT161099 NZ_CP071026:c14297-13995 [Enterobacter hormaechei]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGATGTTGTTGCCAAAGCACAGAAAGCGGCGACTGAAAT
GTTGCTGAACATCCACCTAGCAGAGCTTCGCTCTCGCATGAAACTCACCCAAGGTGAAATTGCTGCTTCTCTGGGGGTTA
AACAACCGACAGTCTCTGATATGGAGAAACCTGGACGAGATCTAAAACTTTCGTCCATTAAGCGCTACGTTGAGGCATCC
GGCGGTAAGCTGCGACTCGATGTGGAACTGCCGGACGGCACCCACTACGGTTTTTCTGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGATGTTGTTGCCAAAGCACAGAAAGCGGCGACTGAAAT
GTTGCTGAACATCCACCTAGCAGAGCTTCGCTCTCGCATGAAACTCACCCAAGGTGAAATTGCTGCTTCTCTGGGGGTTA
AACAACCGACAGTCTCTGATATGGAGAAACCTGGACGAGATCTAAAACTTTCGTCCATTAAGCGCTACGTTGAGGCATCC
GGCGGTAAGCTGCGACTCGATGTGGAACTGCCGGACGGCACCCACTACGGTTTTTCTGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|