Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 691754..692447 Replicon chromosome
Accession NZ_CP055024
Organism Shigella flexneri strain SWHEFF_67

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ75_RS03400 Protein ID WP_000415584.1
Coordinates 691754..692050 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ75_RS03405 Protein ID WP_000650107.1
Coordinates 692052..692447 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ75_RS03365 (686842) 686842..687156 - 315 WP_072711540.1 putative quinol monooxygenase -
HUZ75_RS03370 (687187) 687187..687768 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUZ75_RS03375 (688087) 688087..688419 + 333 WP_000917684.1 DUF2645 family protein -
HUZ75_RS03380 (688465) 688465..689814 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUZ75_RS03385 (689811) 689811..690470 - 660 WP_209153050.1 quorum sensing response regulator transcription factor QseB -
HUZ75_RS03390 (690622) 690622..691014 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ75_RS03395 (691067) 691067..691549 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ75_RS03400 (691754) 691754..692050 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ75_RS03405 (692052) 692052..692447 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ75_RS03410 (692580) 692580..694187 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUZ75_RS03415 (694325) 694325..696583 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T161074 WP_000415584.1 NZ_CP055024:691754-692050 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T161074 NZ_CP071021:c1080529-1080311 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT161074 WP_000650107.1 NZ_CP055024:692052-692447 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT161074 NZ_CP071021:c1080932-1080558 [Enterobacter hormaechei]
TTGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References