Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 760581..761356 Replicon chromosome
Accession NZ_CP055003
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag HUZ54_RS03815 Protein ID WP_021314147.1
Coordinates 760871..761356 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HUZ54_RS03810 Protein ID WP_004150912.1
Coordinates 760581..760874 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS03790 (HUZ54_03780) 755789..756391 - 603 WP_021440720.1 short chain dehydrogenase -
HUZ54_RS03795 (HUZ54_03785) 756489..757400 + 912 WP_004188550.1 LysR family transcriptional regulator -
HUZ54_RS03800 (HUZ54_03790) 757401..758549 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HUZ54_RS03805 (HUZ54_03795) 758560..759936 - 1377 WP_004217775.1 cystathionine beta-synthase -
HUZ54_RS03810 (HUZ54_03800) 760581..760874 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HUZ54_RS03815 (HUZ54_03805) 760871..761356 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
HUZ54_RS03820 (HUZ54_03810) 762060..762653 + 594 WP_004188553.1 hypothetical protein -
HUZ54_RS03825 (HUZ54_03815) 762750..762966 + 217 Protein_752 transposase -
HUZ54_RS03835 (HUZ54_03825) 763807..764520 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 762750..762902 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T160916 WP_021314147.1 NZ_CP055003:760871-761356 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T160916 NZ_CP070964:56270-56542 [Staphylococcus sp. SB1-57]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCTTGATAAAAAATTATT
AAAAAAGATTAACCATTTGATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATCATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT160916 WP_004150912.1 NZ_CP055003:760581-760874 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT160916 NZ_CP070964:56023-56277 [Staphylococcus sp. SB1-57]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAACGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTATTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References