Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 369299..369945 Replicon chromosome
Accession NZ_CP055003
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag HUZ54_RS01710 Protein ID WP_016529833.1
Coordinates 369299..369646 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag HUZ54_RS01715 Protein ID WP_004174017.1
Coordinates 369646..369945 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS01700 (HUZ54_01690) 365225..366658 + 1434 WP_002920564.1 glycogen synthase GlgA -
HUZ54_RS01705 (HUZ54_01695) 366676..369123 + 2448 WP_002920561.1 glycogen phosphorylase -
HUZ54_RS01710 (HUZ54_01700) 369299..369646 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ54_RS01715 (HUZ54_01705) 369646..369945 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
HUZ54_RS01720 (HUZ54_01710) 370008..371516 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HUZ54_RS01725 (HUZ54_01715) 371721..372050 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HUZ54_RS01730 (HUZ54_01720) 372101..372931 + 831 WP_032428425.1 rhomboid family intramembrane serine protease GlpG -
HUZ54_RS01735 (HUZ54_01725) 372981..373739 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T160915 WP_016529833.1 NZ_CP055003:369299-369646 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T160915 NZ_CP070964:56023-56277 [Staphylococcus sp. SB1-57]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAACGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTATTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT160915 WP_004174017.1 NZ_CP055003:369646-369945 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT160915 NZ_CP070964:56270-56542 [Staphylococcus sp. SB1-57]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCTTGATAAAAAATTATT
AAAAAAGATTAACCATTTGATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATCATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References