Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 3725205..3725746 | Replicon | chromosome |
| Accession | NZ_CP055000 | ||
| Organism | Shigella flexneri strain STIN_80 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | S1FHQ9 |
| Locus tag | HUZ55_RS18575 | Protein ID | WP_000615979.1 |
| Coordinates | 3725468..3725746 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | S1EWQ0 |
| Locus tag | HUZ55_RS18570 | Protein ID | WP_000729704.1 |
| Coordinates | 3725205..3725465 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ55_RS18550 (3720888) | 3720888..3721673 | - | 786 | WP_072132640.1 | putative lateral flagellar export/assembly protein LafU | - |
| HUZ55_RS18555 (3721645) | 3721645..3723357 | + | 1713 | Protein_3650 | flagellar biosynthesis protein FlhA | - |
| HUZ55_RS18560 (3723573) | 3723573..3724070 | - | 498 | WP_000006261.1 | REP-associated tyrosine transposase RayT | - |
| HUZ55_RS18565 (3724246) | 3724246..3725019 | - | 774 | WP_001353765.1 | C40 family peptidase | - |
| HUZ55_RS18570 (3725205) | 3725205..3725465 | + | 261 | WP_000729704.1 | type II toxin-antitoxin system antitoxin DinJ | Antitoxin |
| HUZ55_RS18575 (3725468) | 3725468..3725746 | + | 279 | WP_000615979.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | Toxin |
| HUZ55_RS18580 (3725902) | 3725902..3726642 | + | 741 | WP_001225679.1 | peptidoglycan meso-diaminopimelic acid protein amidase | - |
| HUZ55_RS18585 (3726613) | 3726613..3727380 | - | 768 | WP_000333379.1 | class II glutamine amidotransferase | - |
| HUZ55_RS18590 (3727586) | 3727586..3728164 | - | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gmhA/lpcA | 3665253..3750460 | 85207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10830.62 Da Isoelectric Point: 10.0702
>T160900 WP_000615979.1 NZ_CP055000:3725468-3725746 [Shigella flexneri]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
Download Length: 279 bp
>T160900 NZ_CP070962:2300966-2301073 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9391.77 Da Isoelectric Point: 5.0758
>AT160900 WP_000729704.1 NZ_CP055000:3725205-3725465 [Shigella flexneri]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
Download Length: 261 bp
>AT160900 NZ_CP070962:c2300919-2300853 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1FHQ9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4ML0 | |
| AlphaFold DB | A0A0E0Y6Z6 |