Detailed information of TA system TA160882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 731295..731988
• Replicon: chromosome
• Accession: NZ_CP055000
• Organism: Shigella flexneri strain STIN_80

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: HUZ55_RS03635
• Protein ID: WP_000415584.1
• Coordinates: 731295..731591 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: HUZ55_RS03640
• Protein ID: WP_000650107.1
• Coordinates: 731593..731988 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ55_RS03600 (726382)	726382..726696	-	315	WP_000958598.1	putative quinol monooxygenase	-
HUZ55_RS03605 (726727)	726727..727308	-	582	WP_096037755.1	NADPH:quinone oxidoreductase MdaB	-
HUZ55_RS03610 (727627)	727627..727960	+	334	Protein_710	DUF2645 family protein	-
HUZ55_RS03615 (728006)	728006..729355	-	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
HUZ55_RS03620 (729352)	729352..730011	-	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
HUZ55_RS03625 (730163)	730163..730555	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
HUZ55_RS03630 (730608)	730608..731090	+	483	WP_000183505.1	GyrI-like domain-containing protein	-
HUZ55_RS03635 (731295)	731295..731591	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
HUZ55_RS03640 (731593)	731593..731988	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
HUZ55_RS03645 (732121)	732121..733728	+	1608	WP_239592404.1	ABC transporter substrate-binding protein	-
HUZ55_RS03650 (733866)	733866..736124	+	2259	WP_096037756.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T160882 WP_000415584.1 NZ_CP055000:731295-731591 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T160882 NZ_CP070959:2314176-2314598 [Thiomicrospira microaerophila]
TTGAGTAAAAAAATCGATTATATGTTGGATACCTGTATCTGTTCGTTCATTATGCGTGAACAACCCTATTGTGTGCTTGA
GAAGCTACAAGCTGCTGTGATGAATGGACATAGGGTGGTGATTTCAGCGATCACCTATCAGGAAATACATTATGGTTTGC
TGGGAAAAAAAGCATCGCCTAAACATGCTTTACTGGTTGCCGAATTTCTAAAACGAATTGATGAGATACTGGCTTGGGAT
AAGCAAGCGGTTGATGCGACGGTTATCGTTCAAAAACAGCTTATGGCCGAGGGTCTGATGATTGGACACAATGACACAGC
CATTGCTGGCCATGCCATATCAACGGGCAGCATTCTTGTCACAAATAATACTCGCGAGTTTGCTAGAGTGAATGGCTTAA
CTTTCGAAGATTGGGTTCATTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT160882 WP_000650107.1 NZ_CP055000:731593-731988 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT160882 NZ_CP070959:2313950-2314183 [Thiomicrospira microaerophila]
ATGAGAACCGTTTCAATATTTAAAAATGCCAAGAATCAAGCGATACGTTTACCGAAAGATATGGAATATGAAGGGATTAG
TCAGCTTGAAATCATCAAGAATGGTGATGAGATTATCCTTCGTCCTGTGCGCCCTAACTGGTTATCGTTTTCTGAGATTG
AAAAGGCCGATGATGACTTTATGCTAGAACGCCAGCGTTTTGTGGCTGATGAGGGGCGTTTTAACTTTGAGTAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65