Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 731295..731988 Replicon chromosome
Accession NZ_CP055000
Organism Shigella flexneri strain STIN_80

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ55_RS03635 Protein ID WP_000415584.1
Coordinates 731295..731591 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ55_RS03640 Protein ID WP_000650107.1
Coordinates 731593..731988 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ55_RS03600 (726382) 726382..726696 - 315 WP_000958598.1 putative quinol monooxygenase -
HUZ55_RS03605 (726727) 726727..727308 - 582 WP_096037755.1 NADPH:quinone oxidoreductase MdaB -
HUZ55_RS03610 (727627) 727627..727960 + 334 Protein_710 DUF2645 family protein -
HUZ55_RS03615 (728006) 728006..729355 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUZ55_RS03620 (729352) 729352..730011 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ55_RS03625 (730163) 730163..730555 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ55_RS03630 (730608) 730608..731090 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ55_RS03635 (731295) 731295..731591 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ55_RS03640 (731593) 731593..731988 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ55_RS03645 (732121) 732121..733728 + 1608 WP_239592404.1 ABC transporter substrate-binding protein -
HUZ55_RS03650 (733866) 733866..736124 + 2259 WP_096037756.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T160882 WP_000415584.1 NZ_CP055000:731295-731591 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T160882 NZ_CP070959:2314176-2314598 [Thiomicrospira microaerophila]
TTGAGTAAAAAAATCGATTATATGTTGGATACCTGTATCTGTTCGTTCATTATGCGTGAACAACCCTATTGTGTGCTTGA
GAAGCTACAAGCTGCTGTGATGAATGGACATAGGGTGGTGATTTCAGCGATCACCTATCAGGAAATACATTATGGTTTGC
TGGGAAAAAAAGCATCGCCTAAACATGCTTTACTGGTTGCCGAATTTCTAAAACGAATTGATGAGATACTGGCTTGGGAT
AAGCAAGCGGTTGATGCGACGGTTATCGTTCAAAAACAGCTTATGGCCGAGGGTCTGATGATTGGACACAATGACACAGC
CATTGCTGGCCATGCCATATCAACGGGCAGCATTCTTGTCACAAATAATACTCGCGAGTTTGCTAGAGTGAATGGCTTAA
CTTTCGAAGATTGGGTTCATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT160882 WP_000650107.1 NZ_CP055000:731593-731988 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT160882 NZ_CP070959:2313950-2314183 [Thiomicrospira microaerophila]
ATGAGAACCGTTTCAATATTTAAAAATGCCAAGAATCAAGCGATACGTTTACCGAAAGATATGGAATATGAAGGGATTAG
TCAGCTTGAAATCATCAAGAATGGTGATGAGATTATCCTTCGTCCTGTGCGCCCTAACTGGTTATCGTTTTCTGAGATTG
AAAAGGCCGATGATGACTTTATGCTAGAACGCCAGCGTTTTGTGGCTGATGAGGGGCGTTTTAACTTTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References