Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 163274..163998 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP054998 | ||
| Organism | Klebsiella pneumoniae strain STIN_84 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2J4YLV3 |
| Locus tag | HUZ56_RS25835 | Protein ID | WP_023292165.1 |
| Coordinates | 163687..163998 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HUZ56_RS25830 | Protein ID | WP_023292164.1 |
| Coordinates | 163274..163690 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ56_RS25800 (HUZ56_25745) | 158859..159266 | + | 408 | WP_226331063.1 | transglycosylase SLT domain-containing protein | - |
| HUZ56_RS25805 (HUZ56_25750) | 159304..159834 | - | 531 | WP_023292160.1 | antirestriction protein | - |
| HUZ56_RS25810 (HUZ56_25755) | 160459..161292 | - | 834 | WP_159215445.1 | N-6 DNA methylase | - |
| HUZ56_RS25815 (HUZ56_25760) | 161339..161569 | - | 231 | WP_004197732.1 | hypothetical protein | - |
| HUZ56_RS25820 (HUZ56_25765) | 161657..162003 | - | 347 | Protein_167 | hypothetical protein | - |
| HUZ56_RS25825 (HUZ56_25770) | 162070..162450 | - | 381 | WP_023292163.1 | hypothetical protein | - |
| HUZ56_RS25830 (HUZ56_25775) | 163274..163690 | - | 417 | WP_023292164.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HUZ56_RS25835 (HUZ56_25780) | 163687..163998 | - | 312 | WP_023292165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| HUZ56_RS25840 (HUZ56_25785) | 164105..164329 | - | 225 | WP_023292166.1 | hypothetical protein | - |
| HUZ56_RS25845 (HUZ56_25790) | 164340..164552 | - | 213 | WP_055323553.1 | hypothetical protein | - |
| HUZ56_RS25850 (HUZ56_25795) | 164615..164944 | - | 330 | WP_165455231.1 | hypothetical protein | - |
| HUZ56_RS25855 (HUZ56_25800) | 164956..165168 | - | 213 | WP_055323555.1 | hypothetical protein | - |
| HUZ56_RS25860 | 165206..165403 | - | 198 | Protein_175 | single-stranded DNA-binding protein | - |
| HUZ56_RS25865 (HUZ56_25805) | 166041..166358 | - | 318 | WP_032747192.1 | hypothetical protein | - |
| HUZ56_RS25870 (HUZ56_25810) | 166373..166723 | - | 351 | WP_023292061.1 | hypothetical protein | - |
| HUZ56_RS25875 (HUZ56_25815) | 166720..166992 | - | 273 | WP_023292062.1 | hypothetical protein | - |
| HUZ56_RS25880 (HUZ56_25820) | 167182..167667 | + | 486 | WP_159215417.1 | cytoplasmic protein | - |
| HUZ56_RS25885 (HUZ56_25825) | 167912..168034 | - | 123 | WP_085842394.1 | Hok/Gef family protein | - |
| HUZ56_RS25890 | 167979..168131 | - | 153 | Protein_181 | DUF5431 family protein | - |
| HUZ56_RS25895 (HUZ56_25830) | 168413..168898 | - | 486 | WP_039025114.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..197765 | 197765 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12497.32 Da Isoelectric Point: 9.9242
>T160878 WP_023292165.1 NZ_CP054998:c163998-163687 [Klebsiella pneumoniae]
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
>T160878 NZ_CP070959:c1948625-1948281 [Thiomicrospira microaerophila]
ATGTGGCAAGTAGTGACGGTTGATTATTTTGATGATTGGTTTTTATCGTTAAACGCAGCCGAACAGCAAGGTATTTTGAC
CGCTATTTTTAAACTGCAATCGATTGGACCGTTATTAGGTCGTCCTGATGTCGATACGCTTTCAGGCGTGCATAGAGTTA
AAAATTTAAAGGAGCTGAGGGTTCAGCATAAAGGCAAGCCGTATCGCGTGTTGTTTGCTTTTGACCCTAAGCGTCAAGCG
GTCATGTTGTGTGGTGGAGATAAAACCGGTGATAAACGTTTTTATGACAGGATGATTCCGATTGCCGAGCGTGAATTTAT
CGCACATCTTGAAAAACTGGATTAG
ATGTGGCAAGTAGTGACGGTTGATTATTTTGATGATTGGTTTTTATCGTTAAACGCAGCCGAACAGCAAGGTATTTTGAC
CGCTATTTTTAAACTGCAATCGATTGGACCGTTATTAGGTCGTCCTGATGTCGATACGCTTTCAGGCGTGCATAGAGTTA
AAAATTTAAAGGAGCTGAGGGTTCAGCATAAAGGCAAGCCGTATCGCGTGTTGTTTGCTTTTGACCCTAAGCGTCAAGCG
GTCATGTTGTGTGGTGGAGATAAAACCGGTGATAAACGTTTTTATGACAGGATGATTCCGATTGCCGAGCGTGAATTTAT
CGCACATCTTGAAAAACTGGATTAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 15462.59 Da Isoelectric Point: 4.4720
>AT160878 WP_023292164.1 NZ_CP054998:c163690-163274 [Klebsiella pneumoniae]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLAARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMRQYGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLAARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMRQYGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
>AT160878 NZ_CP070959:c1948271-1947969 [Thiomicrospira microaerophila]
ATGGCAAAACCTTTAGCGGATTTATTGCTAAAAATCGATCCGGCGATTGTTGAAGCCGCGCAAAATCAAGCCGAAGAGGA
CGTGCTAGCTTGGCGTTTGGCTTATTTGCGTGAACAGTTGGCGCTTTCGCAAGTAGAAATGGCGGAGCGTTTGGGGATTT
CACAGCCTTCAGTGGCTAACTTAGAAAAACGCGGCCACGAGGTGAAGTTGTCTTCGCTTAAACGTTATGTGGAGGCGCTA
GGCGGCAAGTTGTCTTTAGATGTGCAACTTCCTGATGGGCGGCACATTGGTATTCATGTTTGA
ATGGCAAAACCTTTAGCGGATTTATTGCTAAAAATCGATCCGGCGATTGTTGAAGCCGCGCAAAATCAAGCCGAAGAGGA
CGTGCTAGCTTGGCGTTTGGCTTATTTGCGTGAACAGTTGGCGCTTTCGCAAGTAGAAATGGCGGAGCGTTTGGGGATTT
CACAGCCTTCAGTGGCTAACTTAGAAAAACGCGGCCACGAGGTGAAGTTGTCTTCGCTTAAACGTTATGTGGAGGCGCTA
GGCGGCAAGTTGTCTTTAGATGTGCAACTTCCTGATGGGCGGCACATTGGTATTCATGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|