Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 743780..744473 Replicon chromosome
Accession NZ_CP054992
Organism Shigella flexneri strain STIN_87

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ57_RS03605 Protein ID WP_000415584.1
Coordinates 743780..744076 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ57_RS03610 Protein ID WP_000650107.1
Coordinates 744078..744473 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ57_RS03570 (738868) 738868..739182 - 315 WP_000958598.1 putative quinol monooxygenase -
HUZ57_RS03575 (739213) 739213..739794 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUZ57_RS03580 (740113) 740113..740445 + 333 WP_000917685.1 DUF2645 family protein -
HUZ57_RS03585 (740491) 740491..741840 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUZ57_RS03590 (741837) 741837..742496 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ57_RS03595 (742648) 742648..743040 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ57_RS03600 (743093) 743093..743575 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ57_RS03605 (743780) 743780..744076 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ57_RS03610 (744078) 744078..744473 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ57_RS03615 (744606) 744606..746213 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUZ57_RS03620 (746351) 746351..748609 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 663398..748609 85211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T160836 WP_000415584.1 NZ_CP054992:743780-744076 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T160836 NZ_CP070951:3212147-3212365 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATATGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT160836 WP_000650107.1 NZ_CP054992:744078-744473 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT160836 NZ_CP070951:3211746-3212120 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAACAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References