Detailed information of TA system TA160720

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4169217..4169475
• Replicon: chromosome
• Accession: NZ_CP054965
• Organism: Escherichia coli strain STIN_95

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HUZ63_RS20170
• Protein ID: WP_000809168.1
• Coordinates: 4169323..4169475 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4169217..4169274 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ63_RS20155	4165046..4166305	-	1260	WP_000494929.1	hypothetical protein	-
HUZ63_RS20160	4166434..4167927	-	1494	WP_001350365.1	sulfatase-like hydrolase/transferase	-
HUZ63_RS20165	4167947..4168708	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4169217..4169274	-	58	-	-	Antitoxin
HUZ63_RS20170	4169323..4169475	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HUZ63_RS20175	4169580..4170710	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HUZ63_RS20180	4170799..4172715	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HUZ63_RS20185	4173087..4173491	+	405	WP_000843692.1	DUF2541 family protein	-
HUZ63_RS20190	4173517..4174230	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T160720 WP_000809168.1 NZ_CP054965:4169323-4169475 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T160720 NZ_CP070900:c6185-5880 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT160720 NZ_CP054965:c4169274-4169217 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin