Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-ohsC/Ldr(toxin)
Location 1378308..1378530 Replicon chromosome
Accession NZ_CP054940
Organism Escherichia coli strain MS6192

Toxin (Protein)


Gene name ldrD Uniprot ID B7LGX8
Locus tag MS6192_RS06640 Protein ID WP_000170965.1
Coordinates 1378308..1378415 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 1378463..1378530 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6192_RS06610 1374163..1374996 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
MS6192_RS06615 1374993..1375385 + 393 WP_000200378.1 invasion regulator SirB2 -
MS6192_RS06620 1375389..1376198 + 810 WP_001257044.1 invasion regulator SirB1 -
MS6192_RS06625 1376234..1377088 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
MS6192_RS06630 1377237..1377344 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein -
- 1377392..1377458 + 67 NuclAT_27 - -
- 1377392..1377458 + 67 NuclAT_27 - -
- 1377392..1377458 + 67 NuclAT_27 - -
- 1377392..1377458 + 67 NuclAT_27 - -
- 1377392..1377458 + 67 NuclAT_29 - -
- 1377392..1377458 + 67 NuclAT_29 - -
- 1377392..1377458 + 67 NuclAT_29 - -
- 1377392..1377458 + 67 NuclAT_29 - -
- 1377392..1377458 + 67 NuclAT_31 - -
- 1377392..1377458 + 67 NuclAT_31 - -
- 1377392..1377458 + 67 NuclAT_31 - -
- 1377392..1377458 + 67 NuclAT_31 - -
- 1377392..1377458 + 67 NuclAT_33 - -
- 1377392..1377458 + 67 NuclAT_33 - -
- 1377392..1377458 + 67 NuclAT_33 - -
- 1377392..1377458 + 67 NuclAT_33 - -
- 1377392..1377458 + 67 NuclAT_35 - -
- 1377392..1377458 + 67 NuclAT_35 - -
- 1377392..1377458 + 67 NuclAT_35 - -
- 1377392..1377458 + 67 NuclAT_35 - -
- 1377392..1377458 + 67 NuclAT_37 - -
- 1377392..1377458 + 67 NuclAT_37 - -
- 1377392..1377458 + 67 NuclAT_37 - -
- 1377392..1377458 + 67 NuclAT_37 - -
- 1377394..1377457 + 64 NuclAT_40 - -
- 1377394..1377457 + 64 NuclAT_40 - -
- 1377394..1377457 + 64 NuclAT_40 - -
- 1377394..1377457 + 64 NuclAT_40 - -
- 1377394..1377457 + 64 NuclAT_42 - -
- 1377394..1377457 + 64 NuclAT_42 - -
- 1377394..1377457 + 64 NuclAT_42 - -
- 1377394..1377457 + 64 NuclAT_42 - -
MS6192_RS06635 1377772..1377879 - 108 WP_000170926.1 type I toxin-antitoxin system toxin Ldr family protein -
- 1377932..1377993 + 62 NuclAT_39 - -
- 1377932..1377993 + 62 NuclAT_39 - -
- 1377932..1377993 + 62 NuclAT_39 - -
- 1377932..1377993 + 62 NuclAT_39 - -
- 1377932..1377993 + 62 NuclAT_41 - -
- 1377932..1377993 + 62 NuclAT_41 - -
- 1377932..1377993 + 62 NuclAT_41 - -
- 1377932..1377993 + 62 NuclAT_41 - -
- 1377932..1377994 + 63 NuclAT_28 - -
- 1377932..1377994 + 63 NuclAT_28 - -
- 1377932..1377994 + 63 NuclAT_28 - -
- 1377932..1377994 + 63 NuclAT_28 - -
- 1377932..1377994 + 63 NuclAT_30 - -
- 1377932..1377994 + 63 NuclAT_30 - -
- 1377932..1377994 + 63 NuclAT_30 - -
- 1377932..1377994 + 63 NuclAT_30 - -
- 1377932..1377994 + 63 NuclAT_32 - -
- 1377932..1377994 + 63 NuclAT_32 - -
- 1377932..1377994 + 63 NuclAT_32 - -
- 1377932..1377994 + 63 NuclAT_32 - -
- 1377932..1377994 + 63 NuclAT_34 - -
- 1377932..1377994 + 63 NuclAT_34 - -
- 1377932..1377994 + 63 NuclAT_34 - -
- 1377932..1377994 + 63 NuclAT_34 - -
- 1377932..1377994 + 63 NuclAT_36 - -
- 1377932..1377994 + 63 NuclAT_36 - -
- 1377932..1377994 + 63 NuclAT_36 - -
- 1377932..1377994 + 63 NuclAT_36 - -
- 1377932..1377994 + 63 NuclAT_38 - -
- 1377932..1377994 + 63 NuclAT_38 - -
- 1377932..1377994 + 63 NuclAT_38 - -
- 1377932..1377994 + 63 NuclAT_38 - -
- 1377932..1377995 + 64 NuclAT_16 - -
- 1377932..1377995 + 64 NuclAT_16 - -
- 1377932..1377995 + 64 NuclAT_16 - -
- 1377932..1377995 + 64 NuclAT_16 - -
- 1377932..1377995 + 64 NuclAT_18 - -
- 1377932..1377995 + 64 NuclAT_18 - -
- 1377932..1377995 + 64 NuclAT_18 - -
- 1377932..1377995 + 64 NuclAT_18 - -
- 1377932..1377995 + 64 NuclAT_20 - -
- 1377932..1377995 + 64 NuclAT_20 - -
- 1377932..1377995 + 64 NuclAT_20 - -
- 1377932..1377995 + 64 NuclAT_20 - -
- 1377932..1377995 + 64 NuclAT_22 - -
- 1377932..1377995 + 64 NuclAT_22 - -
- 1377932..1377995 + 64 NuclAT_22 - -
- 1377932..1377995 + 64 NuclAT_22 - -
- 1377932..1377995 + 64 NuclAT_24 - -
- 1377932..1377995 + 64 NuclAT_24 - -
- 1377932..1377995 + 64 NuclAT_24 - -
- 1377932..1377995 + 64 NuclAT_24 - -
- 1377932..1377995 + 64 NuclAT_26 - -
- 1377932..1377995 + 64 NuclAT_26 - -
- 1377932..1377995 + 64 NuclAT_26 - -
- 1377932..1377995 + 64 NuclAT_26 - -
MS6192_RS06640 1378308..1378415 - 108 WP_000170965.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 1378463..1378530 + 68 NuclAT_15 - Antitoxin
- 1378463..1378530 + 68 NuclAT_15 - Antitoxin
- 1378463..1378530 + 68 NuclAT_15 - Antitoxin
- 1378463..1378530 + 68 NuclAT_15 - Antitoxin
- 1378463..1378530 + 68 NuclAT_17 - Antitoxin
- 1378463..1378530 + 68 NuclAT_17 - Antitoxin
- 1378463..1378530 + 68 NuclAT_17 - Antitoxin
- 1378463..1378530 + 68 NuclAT_17 - Antitoxin
- 1378463..1378530 + 68 NuclAT_19 - Antitoxin
- 1378463..1378530 + 68 NuclAT_19 - Antitoxin
- 1378463..1378530 + 68 NuclAT_19 - Antitoxin
- 1378463..1378530 + 68 NuclAT_19 - Antitoxin
- 1378463..1378530 + 68 NuclAT_21 - Antitoxin
- 1378463..1378530 + 68 NuclAT_21 - Antitoxin
- 1378463..1378530 + 68 NuclAT_21 - Antitoxin
- 1378463..1378530 + 68 NuclAT_21 - Antitoxin
- 1378463..1378530 + 68 NuclAT_23 - Antitoxin
- 1378463..1378530 + 68 NuclAT_23 - Antitoxin
- 1378463..1378530 + 68 NuclAT_23 - Antitoxin
- 1378463..1378530 + 68 NuclAT_23 - Antitoxin
- 1378463..1378530 + 68 NuclAT_25 - Antitoxin
- 1378463..1378530 + 68 NuclAT_25 - Antitoxin
- 1378463..1378530 + 68 NuclAT_25 - Antitoxin
- 1378463..1378530 + 68 NuclAT_25 - Antitoxin
MS6192_RS06645 1378820..1379920 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
MS6192_RS06650 1380190..1380420 + 231 WP_001146442.1 putative cation transport regulator ChaB -
MS6192_RS06655 1380578..1381273 + 696 WP_001355927.1 glutathione-specific gamma-glutamylcyclotransferase -
MS6192_RS06660 1381317..1381670 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
MS6192_RS06665 1381855..1383249 + 1395 WP_000086213.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4001.77 Da        Isoelectric Point: 11.4779

>T160649 WP_000170965.1 NZ_CP054940:c1378415-1378308 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T160649 NZ_CP070602:c2617222-2616839 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 68 bp

>AT160649 NZ_CP054940:1378463-1378530 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y029

Antitoxin

Download structure file

References