Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 795194..795894 Replicon chromosome
Accession NZ_CP054932
Organism Actinomadura sp. NAK00032

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HUT06_RS03830 Protein ID WP_176194432.1
Coordinates 795520..795894 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HUT06_RS03825 Protein ID WP_176194431.1
Coordinates 795194..795523 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT06_RS03810 790289..792028 + 1740 WP_176194428.1 hydantoinase B/oxoprolinase family protein -
HUT06_RS03815 792021..793529 + 1509 WP_176194429.1 GMC family oxidoreductase N-terminal domain-containing protein -
HUT06_RS03820 793560..794900 + 1341 WP_176194430.1 aldehyde dehydrogenase family protein -
HUT06_RS03825 795194..795523 - 330 WP_176194431.1 XRE family transcriptional regulator Antitoxin
HUT06_RS03830 795520..795894 - 375 WP_176194432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT06_RS03845 796543..797889 + 1347 WP_176201124.1 amino acid permease -
HUT06_RS03850 797899..799602 + 1704 WP_176194433.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14057.96 Da        Isoelectric Point: 4.5931

>T160636 WP_176194432.1 NZ_CP054932:c795894-795520 [Actinomadura sp. NAK00032]
VAWDVILLEPVESWFLKLCESETDTAALIEQAIDRLAEIGPTLGRPLVDTLEHSELRNLKELRPGSRGRSEIRMLFVFDP
DRAAIFLVAGDKAGQWSRWYDEAIPLAEGRYAEYRAAKDKEAGR

Download         Length: 375 bp

>T160636 NZ_CP070598:c2708599-2707277 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11973.58 Da        Isoelectric Point: 8.6424

>AT160636 WP_176194431.1 NZ_CP054932:c795523-795194 [Actinomadura sp. NAK00032]
MSTGRRWQDIKAEAHRLNPELADPERQARARAELDAYVAGHHLKELRKAVGKTQAEVAQILRVSQSRVSQIENGNLEAME
LETLRAYAAALGGHLDITVSVGPHSIKVA

Download         Length: 330 bp

>AT160636 NZ_CP070598:c2708865-2708599 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References