Detailed information of TA system TA160633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3093006..3093514
• Replicon: chromosome
• Accession: NZ_CP054926
• Organism: Streptomyces fulvissimus strain NA06532

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: N0CS17
• Locus tag: HUT09_RS13560
• Protein ID: WP_015609077.1
• Coordinates: 3093254..3093514 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: N0CVS4
• Locus tag: HUT09_RS13555
• Protein ID: WP_015609076.1
• Coordinates: 3093006..3093257 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT09_RS13545	3089354..3091000	-	1647	WP_176143845.1	PQQ-binding-like beta-propeller repeat protein	-
HUT09_RS13550	3091046..3092866	-	1821	WP_176143846.1	ABC-F family ATP-binding cassette domain-containing protein	-
HUT09_RS13555	3093006..3093257	+	252	WP_015609076.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HUT09_RS13560	3093254..3093514	+	261	WP_015609077.1	Txe/YoeB family addiction module toxin	Toxin
HUT09_RS13565	3093502..3094887	-	1386	WP_176143847.1	acyltransferase	-
HUT09_RS13570	3095141..3095671	+	531	WP_176143848.1	PASTA domain-containing protein	-
HUT09_RS13575	3095784..3096422	+	639	WP_176143849.1	class I SAM-dependent methyltransferase	-
HUT09_RS13580	3096469..3096960	+	492	WP_094212628.1	DinB family protein	-
HUT09_RS13585	3096993..3097898	-	906	WP_176143850.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10452.79 Da
• Isoelectric Point: 9.4245

>T160633 WP_015609077.1 NZ_CP054926:3093254-3093514 [Streptomyces fulvissimus]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T160633 NZ_CP070598:772113-772598 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.37 Da
• Isoelectric Point: 4.4118

>AT160633 WP_015609076.1 NZ_CP054926:3093006-3093257 [Streptomyces fulvissimus]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVQE
LAE

Nucleotide

• Length: 252 bp

>AT160633 NZ_CP070598:771823-772116 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: N0CS17

Antitoxin

• AlphaFold DB: N0CVS4