Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2505190..2505713 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag HUW54_RS12520 Protein ID WP_000074045.1
Coordinates 2505190..2505456 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag HUW54_RS12525 Protein ID WP_000587619.1
Coordinates 2505456..2505713 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS12500 2500496..2501683 - 1188 WP_175528739.1 MFS transporter -
HUW54_RS12505 2502079..2502855 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HUW54_RS12510 2502848..2503510 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
HUW54_RS12515 2503758..2504834 - 1077 WP_001076673.1 M42 family metallopeptidase -
HUW54_RS12520 2505190..2505456 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
HUW54_RS12525 2505456..2505713 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUW54_RS12530 2505819..2506013 - 195 WP_001790145.1 hypothetical protein -
HUW54_RS12535 2506072..2506527 + 456 WP_000732090.1 YehR family lipoprotein -
HUW54_RS12540 2506695..2508272 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
HUW54_RS12545 2508467..2509216 + 750 WP_000072440.1 hypothetical protein -
HUW54_RS12550 2509447..2510640 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T160583 WP_000074045.1 NZ_CP054876:c2505456-2505190 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T160583 NZ_CP070579:c3349916-3349814 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT160583 WP_000587619.1 NZ_CP054876:c2505713-2505456 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT160583 NZ_CP070579:3349808-3349952 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References