Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2473689..2473873 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag HUW54_RS12380 Protein ID WP_000482652.1
Coordinates 2473766..2473873 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2473689..2473749 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS12365 2469144..2469311 - 168 WP_001790576.1 hypothetical protein -
HUW54_RS12370 2469542..2471275 - 1734 WP_000486495.1 ABC transporter ATP-binding protein/permease -
HUW54_RS12375 2471300..2473063 - 1764 WP_001064837.1 ABC transporter ATP-binding protein/permease -
- 2473689..2473749 + 61 - - Antitoxin
HUW54_RS12380 2473766..2473873 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
HUW54_RS12385 2474007..2474393 - 387 WP_000779357.1 flippase GtxA -
HUW54_RS12390 2474661..2475803 + 1143 WP_001176863.1 glycerate kinase -
HUW54_RS12395 2475863..2476522 + 660 WP_000831298.1 membrane protein -
HUW54_RS12400 2476704..2477915 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
HUW54_RS12405 2478038..2478511 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T160581 WP_000482652.1 NZ_CP054876:c2473873-2473766 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T160581 NZ_CP070579:c1239602-1239384 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 61 bp

>AT160581 NZ_CP054876:2473689-2473749 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References