Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2448383..2448900 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HUW54_RS12245 Protein ID WP_000113262.1
Coordinates 2448383..2448649 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HUW54_RS12250 Protein ID WP_000584499.1
Coordinates 2448649..2448900 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS12215 2443812..2444348 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
HUW54_RS12220 2444581..2445405 - 825 WP_000572040.1 formate/nitrite transporter family protein -
HUW54_RS12225 2445622..2445804 - 183 WP_000230294.1 hypothetical protein -
HUW54_RS12230 2445888..2446355 - 468 WP_000153346.1 SRPBCC domain-containing protein -
HUW54_RS12235 2446541..2448088 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HUW54_RS12240 2448277..2448348 - 72 Protein_2364 hypothetical protein -
HUW54_RS12245 2448383..2448649 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HUW54_RS12250 2448649..2448900 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUW54_RS12255 2449065..2449166 - 102 Protein_2367 hypothetical protein -
HUW54_RS12260 2449173..2449772 - 600 WP_000162810.1 DsbA family protein -
HUW54_RS12265 2449791..2450153 - 363 WP_000819843.1 DUF4467 domain-containing protein -
HUW54_RS12270 2450408..2451658 + 1251 WP_001012218.1 FemA/FemB family glycyltransferase FmhA -
HUW54_RS12275 2451755..2452486 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HUW54_RS12280 2452483..2453202 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T160580 WP_000113262.1 NZ_CP054876:c2448649-2448383 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T160580 NZ_CP054876:c2448649-2448383 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT160580 WP_000584499.1 NZ_CP054876:c2448900-2448649 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT160580 NZ_CP054876:c2448900-2448649 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References