Detailed information of TA system TA160579

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2199843..2200060
• Replicon: chromosome
• Accession: NZ_CP054876
• Organism: Staphylococcus aureus strain Dresden-275757

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HUW54_RS10955
• Protein ID: WP_001802298.1
• Coordinates: 2199956..2200060 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2199843..2199898 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW54_RS10935	2195980..2196645	-	666	WP_001024094.1	SDR family oxidoreductase	-
HUW54_RS10940	2196797..2197117	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HUW54_RS10945	2197119..2198099	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HUW54_RS10950	2198365..2199456	+	1092	WP_000495670.1	lytic regulatory protein	-
-	2199843..2199898	+	56	-	-	Antitoxin
HUW54_RS10955	2199956..2200060	-	105	WP_001802298.1	hypothetical protein	Toxin
HUW54_RS10960	2200740..2200898	+	159	WP_001792784.1	hypothetical protein	-
HUW54_RS10965	2201556..2202413	-	858	WP_000370929.1	Cof-type HAD-IIB family hydrolase	-
HUW54_RS10970	2202481..2203263	-	783	WP_000908179.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T160579 WP_001802298.1 NZ_CP054876:c2200060-2199956 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T160579 NZ_CP070579:524943-525227 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT160579 NZ_CP054876:2199843-2199898 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin