Detailed information of TA system TA160572

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2025614..2025913
• Replicon: chromosome
• Accession: NZ_CP054876
• Organism: Staphylococcus aureus strain Dresden-275757

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: HUW54_RS09995
• Protein ID: WP_077446684.1
• Coordinates: 2025737..2025913 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2025614..2025669 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW54_RS09955	2021175..2021354	+	180	WP_000669789.1	hypothetical protein	-
HUW54_RS09960	2021665..2021925	+	261	WP_001791826.1	hypothetical protein	-
HUW54_RS09965	2021978..2022328	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
HUW54_RS09970	2022837..2023172	-	336	Protein_1924	SH3 domain-containing protein	-
HUW54_RS09975	2023822..2024313	-	492	WP_000919350.1	staphylokinase	-
HUW54_RS09980	2024504..2025259	-	756	WP_000861038.1	CHAP domain-containing protein	-
HUW54_RS09985	2025271..2025525	-	255	WP_000611512.1	phage holin	-
HUW54_RS09990	2025577..2025684	+	108	WP_001791821.1	hypothetical protein	-
-	2025606..2025745	+	140	NuclAT_0	-	-
-	2025606..2025745	+	140	NuclAT_0	-	-
-	2025606..2025745	+	140	NuclAT_0	-	-
-	2025606..2025745	+	140	NuclAT_0	-	-
-	2025614..2025669	+	56	-	-	Antitoxin
HUW54_RS09995	2025737..2025913	-	177	WP_077446684.1	putative holin-like toxin	Toxin
HUW54_RS10000	2026065..2026361	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
HUW54_RS10005	2026419..2026706	-	288	WP_001040261.1	hypothetical protein	-
HUW54_RS10010	2026753..2026905	-	153	WP_001153681.1	hypothetical protein	-
HUW54_RS10015	2026895..2030680	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2021978..2076985	55007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6844.44 Da
• Isoelectric Point: 9.9479

>T160572 WP_077446684.1 NZ_CP054876:c2025913-2025737 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKFIELSNKK

Nucleotide

• Length: 177 bp

>T160572 NZ_CP070574:4630-4917 [Proteus mirabilis]
ATGATGTATTCGGTTAAATTTAGAAAAGATGCAGAAAAGGAATGGAAAAAATTAGATAAAACCATTCAATCTCAATTTGC
CAAACAATTAATAAAACGATGTGAAAATCCACATGTAGCATCTGCAAAACTGAGAAATATGCCGAATTGCTATAAAATTA
AACTTCGTGCATCAGGTTTTAGATTGGTCTATCAAGTTATTGACGATATGTTAATTATTGCAGTTGTTGCCGTTGGCAAG
CGGGAAAAAAGTCAGGTTTATAATCTTGCCAGTGAACGCTTAAAATAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT160572 NZ_CP054876:2025614-2025669 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin