Detailed information of TA system TA160567

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1549142..1549721
• Replicon: chromosome
• Accession: NZ_CP054876
• Organism: Staphylococcus aureus strain Dresden-275757

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HUW54_RS07445
• Protein ID: WP_001025401.1
• Coordinates: 1549476..1549721 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1549142..1549507 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW54_RS07405	1545884..1546441	-	558	WP_175528724.1	DUF2815 family protein	-
HUW54_RS07410	1546467..1547633	-	1167	WP_000762551.1	DUF2800 domain-containing protein	-
HUW54_RS07415	1547630..1547992	-	363	WP_000279446.1	hypothetical protein	-
HUW54_RS07420	1548007..1548330	-	324	WP_000175000.1	hypothetical protein	-
HUW54_RS07425	1548410..1548571	-	162	WP_001285955.1	DUF1270 family protein	-
HUW54_RS07430	1548584..1548847	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HUW54_RS07435	1548872..1549087	-	216	WP_001036301.1	hypothetical protein	-
HUW54_RS07440	1549142..1549507	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HUW54_RS07445	1549476..1549721	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HUW54_RS07450	1549737..1549985	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
HUW54_RS07455	1550149..1550472	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	-
HUW54_RS07460	1550485..1550946	+	462	WP_000525006.1	hypothetical protein	-
HUW54_RS07465	1550963..1551397	+	435	WP_175528725.1	hypothetical protein	-
HUW54_RS07470	1551426..1551821	+	396	WP_000449655.1	hypothetical protein	-
HUW54_RS07475	1551911..1552057	+	147	WP_001013104.1	hypothetical protein	-
HUW54_RS07480	1552054..1552668	-	615	WP_000191459.1	hypothetical protein	-
HUW54_RS07485	1552794..1554000	+	1207	Protein_1467	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1502891..1571643	68752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T160567 WP_001025401.1 NZ_CP054876:c1549721-1549476 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T160567 NZ_CP070572:1916631-1917155 [Proteus mirabilis]
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT160567 NZ_CP054876:1549142-1549507 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin