Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4000634..4001288 Replicon chromosome
Accession NZ_CP054874
Organism Pseudomonas protegens strain PGNL1

Toxin (Protein)


Gene name higB Uniprot ID A0A2C9EQ14
Locus tag HUT20_RS18345 Protein ID WP_015636300.1
Coordinates 4000938..4001288 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q4K9S2
Locus tag HUT20_RS18340 Protein ID WP_011062198.1
Coordinates 4000634..4000951 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT20_RS18320 (HUT20_18320) 3995937..3996689 - 753 WP_015636303.1 UDP-2,3-diacylglucosamine diphosphatase -
HUT20_RS18325 (HUT20_18325) 3996686..3997189 - 504 WP_011062201.1 peptidylprolyl isomerase -
HUT20_RS18330 (HUT20_18330) 3997460..3999160 + 1701 WP_015636302.1 glutamine--tRNA ligase/YqeY domain fusion protein -
HUT20_RS18335 (HUT20_18335) 3999179..4000561 + 1383 WP_015636301.1 cysteine--tRNA ligase -
HUT20_RS18340 (HUT20_18340) 4000634..4000951 - 318 WP_011062198.1 transcriptional regulator Antitoxin
HUT20_RS18345 (HUT20_18345) 4000938..4001288 - 351 WP_015636300.1 hypothetical protein Toxin
HUT20_RS18350 (HUT20_18350) 4001526..4002989 - 1464 WP_015636299.1 NADH-quinone oxidoreductase subunit NuoN -
HUT20_RS18355 (HUT20_18355) 4002997..4004529 - 1533 WP_210480731.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 14008.14 Da        Isoelectric Point: 8.9805

>T160563 WP_015636300.1 NZ_CP054874:c4001288-4000938 [Pseudomonas protegens]
MNALFIELPAFARYRKGFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFIDERRNKGRRGGLRVIYYWWSEGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T160563 NZ_CP070571:46536-46952 [Proteus mirabilis]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12064.95 Da        Isoelectric Point: 10.4439

>AT160563 WP_011062198.1 NZ_CP054874:c4000951-4000634 [Pseudomonas protegens]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLEKLPPITAAEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRAIP
NAQATTLIRLVERYPDTVERLASLA

Download         Length: 318 bp

>AT160563 NZ_CP070571:46309-46539 [Proteus mirabilis]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EQ14

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EPZ9

References