160512

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2824231..2824733 Replicon chromosome
Accession NZ_CP054844
Organism Pseudomonas aeruginosa strain SE5357

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag HUS11_RS13685 Protein ID WP_023081358.1
Coordinates 2824479..2824733 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag HUS11_RS13680 Protein ID WP_004350479.1
Coordinates 2824231..2824482 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS11_RS13655 2819343..2819987 + 645 WP_003090351.1 UvrY/SirA/GacA family response regulator transcription factor -
HUS11_RS13660 2819988..2821814 + 1827 WP_003162160.1 excinuclease ABC subunit UvrC -
HUS11_RS13665 2821848..2822408 + 561 WP_003090349.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
HUS11_RS13675 2822776..2824146 + 1371 WP_023081359.1 tyrosine-type recombinase/integrase -
HUS11_RS13680 2824231..2824482 + 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUS11_RS13685 2824479..2824733 + 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
HUS11_RS13690 2824959..2825354 + 396 WP_023081357.1 DUF3742 family protein -
HUS11_RS13695 2825362..2826882 - 1521 WP_004350477.1 conjugal transfer protein TraG N-terminal domain-containing protein -
HUS11_RS13700 2826897..2827247 - 351 WP_023081356.1 hypothetical protein -
HUS11_RS13705 2827435..2828298 - 864 WP_004350470.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T160512 WP_023081358.1 NZ_CP054844:2824479-2824733 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

>T160512 NZ_CP070549:423277-423609 [Citrobacter freundii]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCAGCATCATTTAATAAGTTCACCCGGCTACCTGTTGTCGTTCCCGTCACTAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCTCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTTGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT160512 WP_004350479.1 NZ_CP054844:2824231-2824482 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp

>AT160512 NZ_CP070549:423019-423276 [Citrobacter freundii]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCTGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References