Detailed information of TA system TA160501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 417796..418313
• Replicon: plasmid unnamed1
• Accession: NZ_CP054841
• Organism: Acidovorax antarcticus strain 16-35-5

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HUK68_RS21265
• Protein ID: WP_175506239.1
• Coordinates: 417796..418062 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HUK68_RS21270
• Protein ID: WP_175506240.1
• Coordinates: 418059..418313 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK68_RS21240	412909..413871	-	963	WP_175506236.1	LysR family transcriptional regulator	-
HUK68_RS21245	414022..415830	+	1809	WP_175506237.1	monovalent cation:proton antiporter-2 (CPA2) family protein	-
HUK68_RS21250	415873..416688	+	816	WP_175506448.1	DUF2789 family protein	-
HUK68_RS21255	416755..417222	-	468	WP_175506238.1	hypothetical protein	-
HUK68_RS21260	417206..417631	-	426	Protein_363	hypothetical protein	-
HUK68_RS21265	417796..418062	-	267	WP_175506239.1	Txe/YoeB family addiction module toxin	Toxin
HUK68_RS21270	418059..418313	-	255	WP_175506240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUK68_RS21275	418639..418794	-	156	WP_175506241.1	hypothetical protein	-
HUK68_RS21280	419143..421062	-	1920	WP_175506242.1	UvrD-helicase domain-containing protein	-
HUK68_RS21285	421275..423251	-	1977	Protein_368	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	adeG	1..642987	642987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10215.59 Da
• Isoelectric Point: 8.8449

>T160501 WP_175506239.1 NZ_CP054841:c418062-417796 [Acidovorax antarcticus]
VSRAIKFLPHAWDDYLYWHGHDKKALKRINALLTEAAREPFVGTGKPEPLVGNLSGYWSRRIDQTNRLVYRATDEDVIVL
ACRYHYGD

Nucleotide

• Length: 267 bp

>T160501 NZ_CP070534:c3144135-3143650 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9436.79 Da
• Isoelectric Point: 7.2786

>AT160501 WP_175506240.1 NZ_CP054841:c418313-418059 [Acidovorax antarcticus]
MRVISFSQARSQFKGVIDRVVADCDVTLIHRRDGENAVLLSESTYNSMLETLHLMQSPANARRLMSAVEQDRKGAAKPHE
LLEP

Nucleotide

• Length: 255 bp

>AT160501 NZ_CP070534:c3144389-3144123 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA