Detailed information of TA system TA160488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1783330..1783848
• Replicon: chromosome
• Accession: NZ_CP054831
• Organism: Staphylococcus saprophyticus strain UTI-045

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HSZ48_RS08800
• Protein ID: WP_011304050.1
• Coordinates: 1783330..1783599 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HSZ48_RS08805
• Protein ID: WP_011304051.1
• Coordinates: 1783600..1783848 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ48_RS08765	1778497..1779405	-	909	WP_081324953.1	IS3 family transposase	-
HSZ48_RS08770	1779366..1780049	-	684	WP_011303343.1	helix-turn-helix domain-containing protein	-
HSZ48_RS08775	1780133..1780240	-	108	WP_175267920.1	hypothetical protein	-
HSZ48_RS08780	1781285..1781695	-	411	WP_069819635.1	YolD-like family protein	-
HSZ48_RS08785	1781705..1781896	-	192	WP_069819636.1	hypothetical protein	-
HSZ48_RS08790	1781992..1782240	-	249	WP_047503483.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
HSZ48_RS08795	1782436..1783110	-	675	WP_001105987.1	IS6-like element IS257 family transposase	-
HSZ48_RS08800	1783330..1783599	-	270	WP_011304050.1	Txe/YoeB family addiction module toxin	Toxin
HSZ48_RS08805	1783600..1783848	-	249	WP_011304051.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HSZ48_RS08810	1784156..1785154	-	999	WP_041785008.1	ThiF family adenylyltransferase	-
HSZ48_RS08815	1785154..1785921	-	768	WP_011304054.1	thiazole synthase	-
HSZ48_RS08820	1785923..1786123	-	201	WP_011304055.1	sulfur carrier protein ThiS	-
HSZ48_RS08825	1786113..1787225	-	1113	WP_175268012.1	FAD-binding oxidoreductase	-
HSZ48_RS08830	1787218..1787802	-	585	WP_041785010.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1782436..1783110	674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10361.96 Da
• Isoelectric Point: 10.1510

>T160488 WP_011304050.1 NZ_CP054831:c1783599-1783330 [Staphylococcus saprophyticus]
MAKLNITFSPQAFEDYEYFQLKDRPMVKRINKLLKSINRDGALGGIGKPEKLVGSLSGYYSRRINQEHRLVYTVNDTSIM
VASCRYHYR

Nucleotide

• Length: 270 bp

>T160488 NZ_CP070528:4071941-4072159 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9483.53 Da
• Isoelectric Point: 4.3525

>AT160488 WP_011304051.1 NZ_CP054831:c1783848-1783600 [Staphylococcus saprophyticus]
VTVKNYTFVRDNFRDMINKVNDDSDTITITTKDRNAVLMSEDDYDAIMETLYLQQNPSNAKHLAESIENLERGNVKSKEI
EI

Nucleotide

• Length: 249 bp

>AT160488 NZ_CP070528:4071540-4071914 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG